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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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The development of highly immunodeficient mouse strains has allowed the reconstitution of functional human immune system components in mice. New-generation humanized mice generated in this manner have been extensively used for modeling viral infections that are exclusively human tropic. Epstein–Barr virus (EBV)-infected humanized mice reproduce cardinal features of EBV-associated B-cell lymphoproliferative disease and EBV-associated hemophagocytic lymphohistiocytosis (HLH). Erosive arthritis morphologically resembling rheumatoid arthritis (RA) has also been recapitulated in these mice. Low-dose EBV infection of humanized mice results in asymptomatic, persistent infection. Innate immune responses involving natural killer cells, EBV-specific adaptive T-cell responses restricted by human major histocompatibility and EBV-specific antibody responses are also elicited in humanized mice. EBV-associated T-/natural killer cell lymphoproliferative disease, by contrast, can be reproducedin a distinct mouse xenograft model. In this review, recent findings on the recapitulation of human EBV infection and pathogenesis in these mouse models, as well as their application to preclinical studies of experimental anti-EBV therapies, are described.
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참고문헌 (24)
참고문헌 신청
Akkina R. / 2013 / New generation humanized mice for virus research : comparative aspects and future prospects / Virology 435 : 14 ~ 28
Barton E / 2011 / Pathogenesis and host control of gammaherpesviruses: lessons from the mouse / Annu Rev Immunol 29 : 351 ~ 397
Blaskovic D / 1980 / Isolation of five strains of herpesviruses from two species of free living small rodents / Acta Virol 24 : 468 ~
Bosma GC / 1983 / A severe combined immunodeficiency mutation in the mouse / Nature 301 : 527 ~ 530
Epstein MA / 1975 / Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). III. Serological and biochemical findings in an animal with reticuloproliferative dise
Barton E / 2011 / Pathogenesis and host control of gammaherpesviruses: lessons from the mouse / Annu Rev Immunol 29 : 351 ~ 397
Blaskovic D / 1980 / Isolation of five strains of herpesviruses from two species of free living small rodents / Acta Virol 24 : 468 ~
Bosma GC / 1983 / A severe combined immunodeficiency mutation in the mouse / Nature 301 : 527 ~ 530
Epstein MA / 1975 / Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). III. Serological and biochemical findings in an animal with reticuloproliferative dise
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