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- 학술저널
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- 2016.1
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Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
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Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)
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Brain somatic mutations in MTOR leading to focal cortical dysplasia
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mTOR Plays an Important Role in the Stemness of Human Fetal Cartilage Progenitor Cells (hFCPCs)
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Cell Cycle Arrest Effects of Extract from Artemisia annuain through Akt/mTOR Signaling Pathway in HCT116 Colon Cancer Cells
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Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
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Thermostable Ω-Transaminase From Sphaerobacter Thermophilus and Its Application For Producing Aromatic Β- and Γ-Amino Acids.
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Extracts fromCinnamomumcamphorainduce G1 Cell Cycle Arrest in HCT116 Colon Cancer Cells via Regulating of Akt/mTOR/p53 signaling Pathway
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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
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Apoptotic Effects of Extracts from Allium Hookeri through Regulating Akt/mTOR/p53 Signaling Pathways in AGS Human Gastric Carcinoma Cells
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mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury
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Biogenic Selenium Nanoparticle Induces Apoptosis and Autophagy in Human Gastric Cancer Cells by Suppressing the PI3K/AKT/mTOR Signaling Pathway
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