개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 434 - 443 (10page)
이용수
초록· 키워드
오류제보하기
The release of neurotransmiter is regulated in the processes of membrane docking and membrane fusion between synaptic vesicles and presynaptic plasma membranes. Synaptic vesicles contain a diverse set of proteins that participate in these processes. Small GTP-binding proteins exist in the synaptic vesicles and are sugested to play roles for the regulation of neurotransmiter release. We have examined a possible role of GTP-binding proteins in the regulation of protein phosphory-lation in the synaptic vesicles. GTPγS stimulated the phosphorylation of 46 kDa protein (p46) with pI value of 5.0-5.2, but GDPβS did not. The p46 was identified as protein interacting with C-kinase 1 (PICK-1) by MALDI-TOF mass spectroscopy an-alysis, and anti-PICK-1 antibody recognized the p46 spot on 2-dimensional gel electrophoresis. Rab guanine nucleotide dissociation inhibitor (RabGDI), which dissociates Rab proteins from SVs, did not affect phosphorylation of p46. Ca2+/ calmodulin (CaM), which causes the smal GTP- binding proteins like Rab3A and RalA to diso-ciate from the membranes and stimulates CaM- dependnet protein kinase(s) and phosphatase, the presence of cyclosporin A and cyclophylin. However, RhoGDI, which dissociates Rho proteins from membranes, reduced the phosphorylation of p46 to the extent of about 50%. These results support that p46 was PICK-1, and its phosphory-lation was stimulated by GTP and Ca2+/CaM di-rectly or indirectly through GTP-binding protein(s) and Ca2+/CaM efector protein(s). The phosphoryl-ation of p46 (PICK-1) by GTP and Ca2+/CaM may be important for the regulation of transporters and neurosecretion.calcium; calmodulin; guanosine triphos-phate; phosphorylation; rho GTP-binding proteins; syn-aptic vesicles
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
식물의 생장과 발달에 있어 Calmodulin의 가능한 역할
한국식물학회 심포지움
1993 .01
-
Calcium-Mediated Signaling in Plants: Calmodulin and $Ca^{2+}$ Calmodulin-Dependent Protein Kinase
식물학회지
1997 .01
-
Inhibition of Voltage-Dependent $Ca^{2＋}$-Channels by $Ca^{2＋}$/Calmodulin Dependent Protein Kinase III
한국동물학회 학술대회
2000 .01
-
Structural Organization of Calmodulin Gene and Expression in Transgenic plants
생명과학
1994 .04
-
Large Conformational Changes and Molecular Recognition in Signal Transduction: Calmodulin and Active Transport/Chemosensory Receptors
한국생물물리학회 학술발표회
1997 .01
-
Calmodulin Regulates the Activity of a Dual-Specificity Protein Phosphatase
한국생명과학회 심포지움
2006 .04
-
Interaction of a Kinesin Superfamily Protein 1A (KIF1A) with Calmodulin
Journal of Life Science
2002 .02
-
Characterization of an Easter Lily Calmodulin cDNA Clone
식물학회지
1996 .01
-
Isolation and Sequencing of Two Calmodulin cDNA Clones from Rice Flower
한국생명과학회 심포지움
2003 .10
-
생쥐 난자 성숙 및 활성화에 미치는 $Ca^{2＋}$Calmodulin dependent protein kinase II의 영향
한국동물학회 학술대회
2000 .01
-
Calmodulin of Olive Flounder Paralichthys olivaceus : Cloning and Expression Analysis
한국해양바이오학회지
2007 .12
-
Ca2+/Calmodulin-Dependent NAD Kinase and Glutamate Decarboxylase : Their Roles in Plant Responses to The Environment
The Plant Pathology Journal
2000 .04
-
Salicylic Acid-Independent Plant Defense Signalling Mediated by Specific Calmodulin Isoforms
한국생명과학회 학술발표회
2000 .01
-
Biochemical Characterization of a Calmodulin-Binding Transcription Factor (OsCBT) in Rice
한국생명과학회 심포지움
2006 .04
-
Distribution of Ca2+/calmodulin-dependent protein kinase II dering the mouse oocyte meiotic maturation
한국동물학회 학술대회
2001 .01
-
Interaction of a Divergent Calmodulin Isoform with an MYB Transcription Factor enhances the Salt Tolerance of Plant
한국생명과학회 심포지움
2006 .04
-
Strategy for increasing gamma-amino butyric acid in plants
한국식물학회 학술발표대회
1999 .01
-
[단신] 광섬유센서를 이용한 Eu(Ⅲ)의 형광분광법적 정량
분석과학
1998 .10
-
$Ca^{2+}$ calmodulin-dependent Activation of Glutamate Decarboxylase and Nicontinamide Adenine Dinucleotide Kinase Isolated from Tobacco Plants
한국동물학회 학술대회
1999 .01
-
Cloning and Sequence Determination of α-Tubulin, β-Tubulin and Flagellar Calmodulin cDNAs of Naegleria gruberi
The Journal of Microbiology
1995 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0