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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 546 - 550 (5page)
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초록· 키워드
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Essential hypertension is a multifactorial disease in which genetic and enviromental factors play an important role. These factors difer in each popul-ation. As there are no existing data for the Turkish population, we investigated four Renin Angioten-tensin converting enzyme (ACE), angiotensinogen (AGN) M235T/T174M and angiotensin II type 1 re-ceptor A1166C polymorphism in 109 hypertensive and 86 normotensive Turkish subjects. Polyme-rase Chain Reaction (PCR) and Restriction Frag-ment Length Polymorphism (RFLP), and agarose gel electrophoresis tecniques were used to deter-mine these polymorphism. The frequencies of per-son that carry ACE D allel (D+ID) was signifi-cantly higher in hypertensive group (9.1% ) than controls (80% ) (P＜ 0.000). M235T TT genotype was also found significantly higher in hypertensives than control group (20% vs 2.7% ; P ＜ 0.001). The frequency of AGN 174M allele was higher in the hypertensive group than control subjects (8.76% vs 4.81% ). Frequency of ATR1 C alele (AC+CC genotypes) was found higher hypertensives than controls (39.4% vs 25.9%; P = 0.054). Our results sugest that an interaction exists between the RAS
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