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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 347 - 352 (6page)
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초록· 키워드
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Skeletogenesis occurs through either intramem-branous or endochondral ossification. In adition, some parts of the skeletal components maintain their cartilaginous characteristics throughout life without mineralization. Runx2 is known to be a cesses. In this study, we examined the expression patterns of two major isoforms of Runx2 in early skeletogenesis. During intramembranous bone for-mation, Runx2-type I (Runx2-I) was widely expres-sed in osteoprogenitor cels and active osteo-blasts, while Runx2-type II (Runx2-I) expression was stringently restricted to cels lining mineral-ized bones. Cels in permanent cartilage expressed colagen type II (Col-I) but never expresed Runx2 or Col-X. These permanent cartilages were wel Runx2-I was negative. In endochondral bone for-mation, Runx2 expression temporarily disappeared in Col-II-positive proliferating chondrocytes, but a secondary surge of Runx2-I expression occurred in the prehypertrophic zone before the minerali-zation of cartilage. Collectively, both Runx2 iso-forms showed very similar expression patterns in active bone forming areas; however, Runx2-I has an exclusive role in the early comitment stage of intramembranous or endochondral bone form-ing processes or in cels surrounding permanent cartilage.
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