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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 733 - 745 (13page)
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Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage.
Recently, we developed a soluble, stable, and potent Ang1 variant, COMP-Ang1. COMP-Ang1 is more potent than native Ang1 in phosphorylating the tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 receptor in lung endothelial cells.
We have used a mouse model for allergic airway disease to determine effects of COMP-Ang1 on allergen- induced bronchial inflammation and airway hyper- responsiveness. These mice develop the following typical pathophysiological features of allergic airway disease in the lungs: increased numbers of inflammatory cells of the airways, airway hyper-responsiveness, increased levels of Th2 cell cytokines (IL-4, IL-5, and IL-13), adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), and chemokines (eotaxin and RANTES), and increased vascular permeability. Intravenous administration of COMP-Ang1 reduced bronchial inflammation and airway hyper-responsiveness. In addition, the increased plasma extravasation in allergic airway disease was significantly reduced by the administration of COMP-Ang1. These results suggest that COMP-Ang1 attenuates airway inflammation and hyper- responsiveness, prevents vascular leakage, and may be used as a therapeutic agent in allergic airway disease.
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참고문헌 (26)
참고문헌 신청
Bousquet J / 2000 / Asthma. From bronchoconstriction to airways inflammation and remodeling 161 : 1720 ~ 1745
Carlson TR / 2001 / Direct cell adhesion to the angiopoietins mediated by integrins 276 : 26516 ~ 26525
Chae JK / 2000 / Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vasculari-zation 20 : 2573 ~ 2578
Cho CH / 2004a / COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity 101 : 5547 ~ 5552
Cho CH / 2004b / Designed angiopoietin-1 variant, COMP-Ang1, protects against radia-tion-induced endothelial cell apoptosis 101 : 5553 ~ 5558
Carlson TR / 2001 / Direct cell adhesion to the angiopoietins mediated by integrins 276 : 26516 ~ 26525
Chae JK / 2000 / Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vasculari-zation 20 : 2573 ~ 2578
Cho CH / 2004a / COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity 101 : 5547 ~ 5552
Cho CH / 2004b / Designed angiopoietin-1 variant, COMP-Ang1, protects against radia-tion-induced endothelial cell apoptosis 101 : 5553 ~ 5558
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