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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 395 - 401 (7page)
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It is well known that exercise can have beneficial effects on insulin resistance transporter. Following up our previous report that caveolin-1 plays an important role in glucose uptake in L6 skeletal muscle cells, we examined whether exercise alters the expression of caveolin-1, and whether exercise-caused changes are muscle fiber and exercise type specific. Fifity week-old Sprague Dawley (SD) rats were trained to climb a ladder and treadmill for 8 weeks and their soleus muscles (SOL) and extensor digitorum longus muscles (EDL) were removed after the last bout of exercise and compared with those from non-exercised animals. We found that the expression of insulin related proteins and caveolins did not change in SOL muscles after exercise. However, in EDL muscles, the expression of insulin receptor β (IRβ) and glucose transporter-4 (GLUT-4) as well as phosphorylation of AKT and with aerobic exercise. Also, caveolin-1 and ca-veolin-3 increased along with insulin related proteins only in EDL muscles by resistance exercise. These results suggest that upregulation of caveolin-1 in the skeletal muscle is fiber specific and exercise type specific, implicating the requirement of the specific mode of exercise to improve insulin sensitivity.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Abulrob A / 2004 / Interactions of EGFR and caveolin-1 in human glioblastoma cells evidence that tyrosine phos-phorylation regulates EGFR association with caveolae 23 : 6967
Atherton PJ / 2004 / Concentrations of signal transduction proteins exercise and insulin responses in rat extensor digitorum longus and soleus muscles 261 : 11 ~ 16
Berchtold MW / 2000 / Calcium ion in skeletal muscle its crucial role for muscle function: its crucial role for muscle function, plasticity, and disease 80 : 1215 ~ 1265
Cao H / 2004 / Oxidative stress acti-vates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and pax
Capanni C / 2003 / Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition 35 : 538 ~ 544
Atherton PJ / 2004 / Concentrations of signal transduction proteins exercise and insulin responses in rat extensor digitorum longus and soleus muscles 261 : 11 ~ 16
Berchtold MW / 2000 / Calcium ion in skeletal muscle its crucial role for muscle function: its crucial role for muscle function, plasticity, and disease 80 : 1215 ~ 1265
Cao H / 2004 / Oxidative stress acti-vates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and pax
Capanni C / 2003 / Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition 35 : 538 ~ 544
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