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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 501 - 507 (7page)
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초록· 키워드
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Adiponectin stimulates cholesterol efflux in macrophages
and low adiponectin may in part contribute to
disturbed reverse cholesterol transport in type 2
diabetes. Monocytes express high levels of annexin A6
that could inhibit cholesterol efflux and it was investigated
whether the atheroprotective effects of adiponectin
are accompanied by changes in annexin A6
levels. Adiponectin reduces annexin A6 protein whereas
mRNA levels are not affected. Adiponectin-mediated
activation of peroxisome proliferator-activated
receptor α (PPARα) and AMP-activated protein kinase
(AMPK) does not account for reduced annexin A6
expression. Further, fatty acids and lipopolysaccharide
that are elevated in obesity do not influence annexin
A6 protein levels. Annexin A6 in monocytes from
overweight probands or type 2 diabetic patients is significantly
elevated compared to monocytes of normal-
weight controls. Monocytic annexin A6 positively
correlates with body mass index and negatively with
systemic adiponectin of the blood donors. Therefore,
the current study demonstrates that adiponectin reduces
annexin A6 in monocytes and thereby may enhance
cholesterol efflux. In agreement with these in vitro
finding an increase of monocytic annexin A6 in type
2 diabetes monocytes was observed.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Arita Y / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochem Biophys Res Commun 257 : 79 ~ 83
Bodzioch M / 1999 / The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease / Nat Genet 22 : 347 ~ 351
Bonora E / 2006 / The metabolic syndrome and cardiovascular disease / Ann Med 38 : 64 ~ 80
Cani PD / 2008 / Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice / Diabetes 57 : 1470 ~ 148
Cavelier C / 2006 / Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1 / Biochim Biophys Acta 1761 : 655 ~ 666
Bodzioch M / 1999 / The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease / Nat Genet 22 : 347 ~ 351
Bonora E / 2006 / The metabolic syndrome and cardiovascular disease / Ann Med 38 : 64 ~ 80
Cani PD / 2008 / Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice / Diabetes 57 : 1470 ~ 148
Cavelier C / 2006 / Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1 / Biochim Biophys Acta 1761 : 655 ~ 666
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