지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 413 - 423 (11page)
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초록· 키워드
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Homophilic interaction of the L1 family of cell adhesion molecules plays a pivotal role in regulating neurite outgrowth and neural cell networking in vivo. Functional defects in L1 family members are associated with neurological disorders such as X-linked mental retardation,multiple sclerosis, low-IQ syndrome, developmental delay, and schizophrenia. Various human tumors with poor prognosis also implicate the role of L1,a representative member of the L1 family of cell adhesion molecules, and ectopic expression of L1 in fibroblastic cells induces metastasis-associated gene expression. Previous studies on L1 homologs indicated that four N-terminal immunoglobulin-like domains form a horseshoe-like structure that mediates homophilic interactions. Various models including the zipper, domain-swap, and symmetry-related models are proposed to be involved in structural mechanism of homophilic interaction of the L1 family members.
Recently, cryo-electron tomography of L1 and crystal structure studies of neurofascin, an L1 family protein,have been performed. This review focuses on recent discoveries of different models and describes the possible structural mechanisms of homophilic interactions of L1 family members. Understanding structural mechanisms of homophilic interactions in various cell adhesion proteins should aid the development of therapeutic strategies for L1 family cell adhesion molecule-associated diseases.
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참고문헌 (23)
참고문헌 신청
Acheson A / 1991 / NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions / J Cell Biol 114 : 143 ~ 153
Arevalo E / 2008 / An alcohol binding site on the neural cell adhesion molecule L1 / Proc Natl Acad Sci USA 105 : 371 ~ 375
Aricescu AR / 2007 / Immunoglobulin superfamily cell adhesion molecules: zippers and signals / Curr Opin Cell Biol 19 : 543 ~ 550
Aricescu AR / 2007 / Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism / Science 317 : 1217 ~ 1220
Bennett V / 2001 / Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues / Physiol Rev 81 : 1353 ~ 1392
Arevalo E / 2008 / An alcohol binding site on the neural cell adhesion molecule L1 / Proc Natl Acad Sci USA 105 : 371 ~ 375
Aricescu AR / 2007 / Immunoglobulin superfamily cell adhesion molecules: zippers and signals / Curr Opin Cell Biol 19 : 543 ~ 550
Aricescu AR / 2007 / Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism / Science 317 : 1217 ~ 1220
Bennett V / 2001 / Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues / Physiol Rev 81 : 1353 ~ 1392
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