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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 10 (10page)
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The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as ‘find-me’ and ‘eat-me’ signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment.
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참고문헌 (24)
참고문헌 신청
Chekeni FB / 2010 / Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis / Nature 467 : 863 ~ 867
Chen YZ / 2013 / Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization / Nat Commun 4 : 2726 ~
Elliott MR / 2009 / Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance / Nature 461 : 282 ~ 286
Fadok VA / 1992 / Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages / J Immunol 148 : 2207 ~ 22
Feng M / 2015 / Macrophages eat cancer cells using their own calreticulin as a guide : roles of TLR and Btk / Proc Natl Acad Sci USA 112 : 2145 ~ 2150
Chen YZ / 2013 / Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization / Nat Commun 4 : 2726 ~
Elliott MR / 2009 / Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance / Nature 461 : 282 ~ 286
Fadok VA / 1992 / Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages / J Immunol 148 : 2207 ~ 22
Feng M / 2015 / Macrophages eat cancer cells using their own calreticulin as a guide : roles of TLR and Btk / Proc Natl Acad Sci USA 112 : 2145 ~ 2150
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