지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 89 - 98 (10page)
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초록· 키워드
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Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavily dependent on high basal autophagy compared to non-neuronal cells as misfolded proteins and damaged organelles cannot be diluted through cell division. Moreover, neurons contain the specialized structures for intercellular communication,such as axons, dendrites and synapses,which require the reciprocal transport of proteins, organelles and autophagosomes over significant distances from the soma. Defects in autophagy affect the intercellular communication and subsequently, contributing to neurodegeneration. The presence of abnormal autophagic activity is frequently observed in selective neuronal populations afflicted in common neurodegenerative diseases, such as Alzheimer’s disease,Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. These observations have provoked controversy regarding whether the increase in autophagosomes observed in the degenerating neurons play a protective role or instead contribute to pathogenic neuronal cell death. It is still unknown what factors may determine whether active autophagy is beneficial or pathogenic during neurodegeneration.
In this review, we consider both the normal and pathophysiological roles of neuronal autophagy and its potential therapeutic implications for common neurodegenerative diseases.
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참고문헌 (25)
참고문헌 신청
Andrade MA / 1995 / HEAT repeats in the Huntington's disease protein / Nat Genet 11 : 115 ~ 116
Anglade P / 1997 / Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease / Histol Histopathol 12 : 25 ~ 31
Atwal RS / 2008 / A stress sensitive ER membraneassociation domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy / Autophagy 4
Boland B / 2008 / Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease / J Neurosci 28 : 6926 ~ 6937
Caccamo A / 2010 / Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments / J Biol Chem 285 : 13107 ~ 13120
Anglade P / 1997 / Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease / Histol Histopathol 12 : 25 ~ 31
Atwal RS / 2008 / A stress sensitive ER membraneassociation domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy / Autophagy 4
Boland B / 2008 / Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease / J Neurosci 28 : 6926 ~ 6937
Caccamo A / 2010 / Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments / J Biol Chem 285 : 13107 ~ 13120
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