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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 109 - 120 (12page)
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Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic integrity by degrading aged or malfunctioning organelles and damaged or misfolded proteins. However, autophagy also plays a complicated role in tumorigenesis and treatment responsiveness. It can be tumor-suppressing during the early stages of tumorigenesis (i.e., it is an anti-tumor mechanism), as reduced autophagy is found in tumor cells and may be associated with malignant transformation. In this case, induction of autophagy would seem to be beneficial for cancer prevention. In established tumors, however, autophagy can be tumor-promoting (i.e., it is a pro-tumor mechanism), and cancer cells can use enhanced autophagy to survive under metabolic and therapeutic stress. The pharmacological and/or genetic inhibition of autophagy was recently shown to sensitize cancer cells to the lethal effects of various cancer therapies, including chemotherapy,radiotherapy and targeted therapies, suggesting that suppression of the autophagic pathway may represent a valuable sensitizing strategy for cancer treatments. In contrast, excessive stimulation of autophagy may also provide a therapeutic strategy for treating resistant cancer cells having high apoptotic thresholds. In order for us to develop successful autophagy-modulating strategies against cancer, we need to better understand how the roles of autophagy differ depending on the tumor stage, cell type and/or genetic factors, and we need to determine how specific pathways of autophagy are activated or inhibited by the various anti-cancer therapies.
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참고문헌 (24)
참고문헌 신청
Aita VM / 1999 / Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21 / Genomics 59 : 59 ~ 65
Amaravadi RK / 2007 / Autophagy inhibition enhances therapy-induced apoptosis in a Mycinduced model of lymphoma / J Clin Invest 117 : 326 ~ 336
Amaravadi RK / 2011 / Principles and current strategies for targeting autophagy for cancer treatment / Clin Cancer Res 17 : 654 ~ 666
Apel A / 2008 / Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy / Cancer Res 68 : 1485 ~ 1494
Arico S / 2001 / The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway / J Biol Chem 276 : 35
Amaravadi RK / 2007 / Autophagy inhibition enhances therapy-induced apoptosis in a Mycinduced model of lymphoma / J Clin Invest 117 : 326 ~ 336
Amaravadi RK / 2011 / Principles and current strategies for targeting autophagy for cancer treatment / Clin Cancer Res 17 : 654 ~ 666
Apel A / 2008 / Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy / Cancer Res 68 : 1485 ~ 1494
Arico S / 2001 / The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway / J Biol Chem 276 : 35
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