지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1 - 9 (9page)
이용수
초록· 키워드
오류제보하기
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38 and induced the nuclear translocation of Bcl-2 and its phosphorylation.
These events inhibited cancer cell proliferation and subsequently enhanced MCF-7 breast cancer cell apoptosis. Bcl-2knockdown using small interfering RNA (siRNA) delayed apoptotic cell death, which correlated with increased proliferation following aspirin exposure. In contrast, Bcl-2 overexpression enhanced the onset of aspirin-induced apoptosis, which was also associated with a significant increase in Bcl-2 phosphorylation in the nucleus. Therefore, this study may provide novel insight into the molecular mechanism of aspirin, particularly its anticancer effects in Bcl-2- and estrogen receptor-positive breast cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Achiwa H / 1999 / Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas / Clin Cancer Res 5 : 1001 ~ 1005
Chan G / 1999 / Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck / Cancer Res 59 : 991 ~ 994
Dalen JE / 2006 / Aspirin to prevent heart attack and stroke: what’s the right dose? / Am J Med 119 : 198 ~ 202
Dasgupta K / 2006 / Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence / Cancer J 12 : 130 ~ 135
Dikshit P / 2006 / Aspirin induces apoptosis through the inhibition of proteasome function / J Biol Chem 281 : 29228 ~ 29235
Chan G / 1999 / Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck / Cancer Res 59 : 991 ~ 994
Dalen JE / 2006 / Aspirin to prevent heart attack and stroke: what’s the right dose? / Am J Med 119 : 198 ~ 202
Dasgupta K / 2006 / Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence / Cancer J 12 : 130 ~ 135
Dikshit P / 2006 / Aspirin induces apoptosis through the inhibition of proteasome function / J Biol Chem 281 : 29228 ~ 29235
이 논문의 저자 정보
최근 본 자료
댓글(0)
0