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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1 - 10 (10page)
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Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both a pro- and anti-inflammatory cytokine. We investigated the in vivo effects of IL-27 on arthritis severity in a murine collagen-induced arthritis (CIA) model and its mechanism of action regarding control of regulatory T (Tregs) and IL-17-producing T helper 17 (Th17) cells. IL-27-Fc-treated CIA mice showed a lower severity of arthritis. IL-17 expression in the spleens was significantly decreased in IL-27-Fc-treated CIA mice compared with that in the CIA model. The Th17 population was decreased in the spleens of IL-27-Fc-treated CIA mice, whereas the CD4þCD25þFoxp3þTreg population increased. In vitro studies revealed that IL-27 inhibited IL-17 production in murine CD4þ T cells, and the effect was associated with retinoic acid-related orphan receptor cT and signal transducer and activator of transcription 3inhibition. In contrast, fluorescein isothiocyanate-labeled forkhead box P3 (Foxp3) and IL-10 were profoundly augmented by IL-27 treatment. Regarding the suppressive capacity of Treg cells, the proportions of CTLA-4þ (cytotoxic T-lymphocyte antigen 4), PD-1þ (programmed cell death protein 1) and GITRþ (glucocorticoid-induced tumor necrosis factor receptor) Tregs increased in the spleens of IL-27-Fc-treated CIA mice. Furthermore, in vitro differentiated Treg cells with IL-27 exerted a more suppressive capacity on T-cell proliferation. We found that IL-27 acts as a reciprocal regulator of the Th17 and Treg populations in CD4þ cells isolated from healthy human peripheral blood mononuclear cells (PBMCs), as well as from humans with rheumatoid arthritis (RA) PBMCs. Our study suggests that IL-27 has the potential to ameliorate overwhelming inflammation in patients with RA through a reciprocal regulation of Th17 and Treg cells.
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참고문헌 (23)
참고문헌 신청
Bettan M / 2000 / High-level protein secretion into blood circulation after electric pulsemediated gene transfer into skeletal muscle / Mol Ther 2 : 204 ~ 210
Francisco LM / 2009 / PD-L1 regulates the development, maintenance, and function of induced regulatory T cells / J Exp Med 206 : 3015 ~ 3029
Goldberg R / 2004 / Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27 / J Immunol 173 : 1171 ~ 1178
Ha SJ / 2003 / Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infectionmodel after aerosol infection of mice with Mycobacterium tuberculosis / Gen
Hirota K / 2007 / Sugimoto N et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model / J Exp
Francisco LM / 2009 / PD-L1 regulates the development, maintenance, and function of induced regulatory T cells / J Exp Med 206 : 3015 ~ 3029
Goldberg R / 2004 / Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27 / J Immunol 173 : 1171 ~ 1178
Ha SJ / 2003 / Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infectionmodel after aerosol infection of mice with Mycobacterium tuberculosis / Gen
Hirota K / 2007 / Sugimoto N et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model / J Exp
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