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- 2015.1
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The rising number of obese individuals has become a major burden to the healthcare systems worldwide. Obesity includes not only the increase of adipose tissue mass but importantly also the altered cellular functions that collectively lead to a chronic state of adipose tissue inflammation, insulin resistance and impaired wound healing. Adipose tissue undergoing chronic inflammation shows altered cytokine expression and an accumulation of adipose tissue macrophages (ATM). The macrophage migration inhibitory factor (MIF) superfamily consists of MIF and the recently identified homolog D-dopachrome tautomerase (D-DT or MIF-2). MIF and D-DT, which both bind to the CD74/CD44 receptor complex, are differentially expressed in adipose tissue and have distinct roles in adipogenesis. MIF positively correlates with obesity as well as insulin resistance and contributes to adipose tissue inflammation by modulating ATM functions. D-DT, however, is negatively correlated with obesity and reverses glucose intolerance. In this review, their respective roles in adipose tissue homeostasis, adipose tissue inflammation, insulin resistance and impaired wound healing will be reviewed.
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참고문헌 (24)
참고문헌 신청
Alvehus M / 2010 / The human visceral fat depot has a unique inflammatory profile / Obesity (Silver Spring) 18 : 879 ~ 883
Atsumi T / 2007 / The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation / J Immunol 179 : 5399 ~ 5406
Bernhagen J / 2007 / MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment / Nat Med 13 : 587 ~ 596
Bloom BR / 1996 / Mechanism of a reaction in vitro associated with delayed-type hypersensitivity / Science 153 : 80 ~ 82
Calandra T / 1995 / MIF as a glucocorticoid-induced modulator of cytokine production / Nature 377 : 68 ~ 71
Atsumi T / 2007 / The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation / J Immunol 179 : 5399 ~ 5406
Bernhagen J / 2007 / MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment / Nat Med 13 : 587 ~ 596
Bloom BR / 1996 / Mechanism of a reaction in vitro associated with delayed-type hypersensitivity / Science 153 : 80 ~ 82
Calandra T / 1995 / MIF as a glucocorticoid-induced modulator of cytokine production / Nature 377 : 68 ~ 71
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