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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 8 (8page)
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Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on diagnostic and therapeutic use of this molecular class of alternative scaffolds, and early clinical evidence is now beginning to accumulate that suggests the Affibody molecules to be efficacious and safe in man. The small size and ease of engineering make Affibody molecules suitable for use in multispecific constructs where AffiMabs is one such that offers the option to potentiate antibodies for use in complex disease.
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참고문헌 (24)
참고문헌 신청
Ahlgren S / 2010 / Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold / J Nucl Med 51
Altai M / 2016 / Influence of molecular design on biodistribution and targeting properties of an Affibody-fused HER2-recognising anticancer toxin / Int J Oncol 49 : 1185 ~ 1
Baum RP / 2010 / Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules / J Nucl Med 51 : 8
Binz HK / 2005 / Engineering novel binding proteins from nonimmunoglobulin domains / Nat Biotechnol 23 : 1257 ~ 1268
Feldwisch J / 2010 / Design of an optimized scaffold for affibody molecules / J Mol Biol 398 : 232 ~ 247
Altai M / 2016 / Influence of molecular design on biodistribution and targeting properties of an Affibody-fused HER2-recognising anticancer toxin / Int J Oncol 49 : 1185 ~ 1
Baum RP / 2010 / Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules / J Nucl Med 51 : 8
Binz HK / 2005 / Engineering novel binding proteins from nonimmunoglobulin domains / Nat Biotechnol 23 : 1257 ~ 1268
Feldwisch J / 2010 / Design of an optimized scaffold for affibody molecules / J Mol Biol 398 : 232 ~ 247
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