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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 572 - 575 (4page)
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초록· 키워드
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The X-ray repair cross-complementing group 1
(XRCC1) gene is believed to play an important role
in base excision repair and displays genetic
polymorphisms. Data on the role of XRCC1 polymorphisms
in cancer susceptibility is inconsistent.
In the present study, we investigated the
effect of two XRCC1 polymorphisms, Arg194Trp
and Arg399Gln, on breast cancer risk in a casecontrol
study involving Turkish breast cancer
patients and healthy women. Both alleles exhibited
a similar distribution among cases and controls
leading to lack of any significant association
between the XRCC1 polymorphisms and breast
cancer risk, either in homozygotes and heterozygotes or combined. The allele frequency of the codon 194 variant was very low in cases and healthy individuals (5.3 and 3.9%, respectively) compared to that of the variant 399Gln allele (39.7 and 37.4%). Our results do not support evidence for a role of the XRCC1 polymorphism in developing breast cancer.
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참고문헌 (20)
참고문헌 신청
/ 1995 / Proportion of breast cancer cases in the United Statesexplained by well-established risk factors : 1681 ~ 5
/ 1996 / Reconstitution of DNA base excision repair withpurified human proteins interaction between DNA polymerasebeta and the XRCC1 protein : 6662 ~ 70
/ 1997 / XRCC1protein interacts with one of two distinct forms of DNA ligaseIII : 5207 ~ 11
/ 1998 / Nonconservativeamino acid substitution variants exist at polymorphic frequencyin DNA repair genes in healthy humans : 604 ~ 8
/ 1998 / Variation in DNA repair is afactor in cancer susceptibility a paradigm for the promisesand perils of individual and population risk estimation : 15 ~ 24
/ 1996 / Reconstitution of DNA base excision repair withpurified human proteins interaction between DNA polymerasebeta and the XRCC1 protein : 6662 ~ 70
/ 1997 / XRCC1protein interacts with one of two distinct forms of DNA ligaseIII : 5207 ~ 11
/ 1998 / Nonconservativeamino acid substitution variants exist at polymorphic frequencyin DNA repair genes in healthy humans : 604 ~ 8
/ 1998 / Variation in DNA repair is afactor in cancer susceptibility a paradigm for the promisesand perils of individual and population risk estimation : 15 ~ 24
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