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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 379 - 390 (12page)
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초록· 키워드
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Since genetic abnormalities of human cancer are greatly geographically dependent, cultural and en-vironmental backgrounds are thought to be closely related to the carcinogenic process. In the present study, eight human cell lines were established by culture from untreated carcinomas of the oral cancer, of which five were from primary oral squamous cell carcinomas (OSC), one from a mucoepidermoid carcinoma (MEC) and one each originating from metastatic OSC and MEC. All the studied tumor lines grew as monolayers, and showed: i) an epithelial origin by the presence of cytokeratin, and ii) tumorigenic potential in nude mice. Western blot analysis revealed i) over expression of EGFR in six of the cell lines ii) decreased expression of E- cadherin in six cell lines compared to normal human mutations of p53 at exon 7, with transversion, and at exon 8, with transition. These well-characterized human YD cell lines should serve as useful tools in the study of the molecular pathogenesis and bio-logical characteristics of head and neck cancer cells, and in the future testing of new therapeutic reagents for oral cancer.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ / Alcohol consumption and cigarette smokingincrease the frequency of p53 mutations in non-small celllung cancer : 3155 ~ 315
/ / Characteristics of four newhuman cell lines derived from squamous cell carcinomas ofthe head and neck : 621 ~ 35
/ / DNA content of humansquamous cell carcinoma cell lines; analysis by flowcytometryand chromosome enumeraion : 565 ~ 75
/ / Establishment andcharacterization of two new squamous cell carcinoma celllines derived from tumours of head and neck 48 : 2858 ~ 66
/ / Establishment of four new squamous cellcarcinoma cell lines derived from oral cancer : 179 ~ 86
/ / Characteristics of four newhuman cell lines derived from squamous cell carcinomas ofthe head and neck : 621 ~ 35
/ / DNA content of humansquamous cell carcinoma cell lines; analysis by flowcytometryand chromosome enumeraion : 565 ~ 75
/ / Establishment andcharacterization of two new squamous cell carcinoma celllines derived from tumours of head and neck 48 : 2858 ~ 66
/ / Establishment of four new squamous cellcarcinoma cell lines derived from oral cancer : 179 ~ 86
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