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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 76 - 82 (7page)
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초록· 키워드
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Interleukin 6 (IL6) plays an essential role in the regulation of imune response to chronic disease. In this study, the thre known single nucleotide polymorphisms (SNPs) in the IL6 promoter region were genotyped in a large chronic hepatitis B cohort to evaluate the effects of IL6 promoter vari-ants. The single base extfor this genotyping. Haplotypes were constructed by the three SNPs in IL6. Allele frequencies were compared for; i) patients with chronic hepatitis (CH) and chronic cariers vs. chronic hepatis pa-tients with clinical evidence of liver cirhosis (LC) (i.e., portal hypertension), ii) cirhotic patients with hepatocelular carcinoma (HCC) vs. without HC by logistic regresion, and iii) with respect to the time intervals from the onset of infection to HC. lysis on the assumption that all the patients were infected during early infancy. The frequencies of each SNP were 0.002 (IL6-597 G＞A), 0.25 (IL6-572 C＞G) and 0.002 (IL6-174 G＞C), respectively, in the Korean population (n = 1,046). No significant associations were detected between IL6-572 C＞G and chronic hepatitis B outcome in this study; i.e., LC occurrence on CH (OR = 0.16-1.27, P= 0 . 1 3 - P= 0.89-0.60) of heterozygotes and homozygotes for G allele in referent comparison to homozygotes for comon allele (C/C genotype), and time in-terval to HCC (RH = 0.67-1.0; P = 0.14-0.99). In conclusion, there appeared to be no significant associations betwen IL6 promoter variants and disease outcome in chronic hepatitis B.
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