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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 78 - 84 (7page)
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초록· 키워드
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Methyl-b-cyclodextrin, a cyclic oligosaccharide known
for its interaction with the plasma membrane induces
several events in cells including cell growth
and anti-tumor activity. In this study, we have investigated
the possible role of cyclooxygenase 2
(COX-2) in cell growth arrest induced by methyl-bcyclodextrin
in Raw264.7 macrophage cells. Methyl- b-cyclodextrin inhibited cell growth and arrested
the cell cycle, and this cell cycle arrest reduced
the population of cells in the S phase, and concomitantly
reduced cyclin A and D expressions.
Methyl-b-cyclodextrin in a dose- and time-dependent
manner, also induced COX-2 expression, prostaglandin
E2 (PGE2) synthesis, and COX-2 promoter
activity. Pretreatment of cells with NS398,
a COX-2 specific inhibitor completely blocked
PGE2 synthesis induced by methyl-b-cyclodextrin,
however inhibition on cell proliferation and cell
cycle arrest was not effected, suggesting nonassociation
of COX-2 in the cell cycle arrest.
These results suggest that methyl-b-cyclodextrin
induced cell growth inhibition and cell cycle arrest
in Raw264.7 cells may be mediated by cyclin A
and D1 expression.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ / Induction of cyclooxygenase-2 by interleukin-1a : 11769 ~ 75
/ 1995 / D-type cyclins
/ 1998 / Cyclooxygenase in biology anddisease : 1063 ~ 73
/ 1998 / Expressionof cyclooxygenase-2 in human airway smooth muscle is associatedwith profound reductions in cell growth : 1102 ~ 8
/ 1998 / Methyl-b-cyclodextrins andliposomes as water-soluble carriers for cholesterol incorporationinto membranes and its evaluation by a microenzymaticfluorescence assay a
/ 1995 / D-type cyclins
/ 1998 / Cyclooxygenase in biology anddisease : 1063 ~ 73
/ 1998 / Expressionof cyclooxygenase-2 in human airway smooth muscle is associatedwith profound reductions in cell growth : 1102 ~ 8
/ 1998 / Methyl-b-cyclodextrins andliposomes as water-soluble carriers for cholesterol incorporationinto membranes and its evaluation by a microenzymaticfluorescence assay a
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