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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 93 - 97 (5page)
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초록· 키워드
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In association with microtubules, a variety of kinesins play im portant roles in cellular functions such as intracellular transport of organelles or vesicles, signal transduction, and cell division. In a previous study we revealed that human kinesin superfamily protein member 4 (KIF4) is a chromokinesin that binds to chromosomes. Since localization of several kinds of kinesin at midzone called central spindle, or midbody that connects two daughter cells, or both, suggests their implication in cell division, we investigated KIF4 localization of during mitosis and cytokinesis in Hela cells. In addition to association with segregating chromosomes through entire mitosis, it also localized to the midzone and to midbody at ana/telophase through cytokinesis. Especially in cells at cytokinesis, KIF4 appeared as a doublet facing each other at the apical ends of two daughter cells. Threedimensional analysis of architectural relationship between microtubule bundles and KIF4 indicated that KIF4 forms a ring structure wrapping around the microtubule bundles. These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study.
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참고문헌 (15)
참고문헌 신청
/ 1995 / Chomokinesin kinesinlikenuclear protein : 761 ~ 68
/ 1995 / Raats J Heasman J Karsenti E WylieC Xklp1 : 117 ~ 27
/ 1998 / Cytokinesisand midzone microtubule organization in Caenorhabditis elegansrequire the kinesin-like protein ZEN-4 : 2037 ~ 49
/ 1998 / Kinesin and dynein superfamily proteins and themechanism of organelle transport : 519 ~ 26
/ 1998 / The vertebrate cell kinetochore andits roles during mitosis : 310 ~ 8
/ 1995 / Raats J Heasman J Karsenti E WylieC Xklp1 : 117 ~ 27
/ 1998 / Cytokinesisand midzone microtubule organization in Caenorhabditis elegansrequire the kinesin-like protein ZEN-4 : 2037 ~ 49
/ 1998 / Kinesin and dynein superfamily proteins and themechanism of organelle transport : 519 ~ 26
/ 1998 / The vertebrate cell kinetochore andits roles during mitosis : 310 ~ 8
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Sequences and Phylogenic Analysis of Squid New Kinesin Superfamily Proteins(KIFs)
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The Regulation Mechanisms of Kinesin Motor Proteins
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APP Tail 1 (PAT1) Interacts with Kinesin Light Chains (KLCs) through the Tetratricopeptide Repeat (TPR) Domain
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Rab Effector EHBP1L1 Associates with the Tetratricopeptide Repeat Domain of Kinesin Light Chain 1
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