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자료유형
학술저널
저자정보
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대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제37권 제4호
발행연도
2005.1
수록면
290 - 296 (7page)

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Epigallocatechin gallate (EGCG) is a principle phenolic antioxidant found in a variety of plants, including green and black tea. The anti-allergic effect of EGCG is unknown. The purpose of this study is to investigate the effects of EGCG on compound 48/80-induced mast cell activation and passive EGCG on the compound 48/80-induced cutaneous reaction were measured in vivo and the effects of EGCG on the compound 48/80-induced mast cell activations were examined in vitro. Results are below: as 1) EGCG significantly inhibited compound 48/80-induced passive cutaneous anaphylaxis, 2) the compound 48/80-induced degranulation, calci-um influx and histamine release of rat peritoneal mast cells (RPMCs) were significantly inhibited by the pretreatment with EGCG, and 3) the compound 48/80-mediated inhibition of cAMP level in RPMCs was significantly increased by the pretreatment with EGCG. These results suggested that EGCG, inhibits the compound 48/80-induced mast cel activation and the increase of vascular per-meability, and potentially serve as effective therapeutic tols for alergic diseases.

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