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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 614 - 627 (14page)
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초록· 키워드
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During membrane depolarization associated with skeletal excitation-contraction (EC) coupling, dihydropyridine receptor [DHPR, a L-type Ca2+ channel in the transverse (t)-tubule membrane] undergoes conformational changes that are transmitted to ryanodine receptor 1 [RyR1, an internal Ca2+-release channel in the sarcoplasmic reticulum (SR) membrane] causing Ca2+ release from the SR. Canonical-type transient receptor potential cation channel 3 (TRPC3), an extracellular Ca2+-entry channel in the t-tubule and plasma membrane, is required for full-gain of skeletal EC coupling. To examine additional role(s) for TRPC3 in skeletal muscle other than mediation of EC coupling,in the present study, we created a stable myoblast line with reduced TRPC3 expression and without α1SDHPR (MDG/TRPC3 KD myoblast) by knock-down of TRPC3in α1SDHPR-null muscular dysgenic (MDG) myoblasts using retrovirus-delivered small interference RNAs in order to eliminate any DHPR-associated EC coupling-related events. Unlike wild-type or α1SDHPR-null MDG myoblasts, MDG/TRPC3 KD myoblasts exhibited dramatic changes in cellular morphology (e.g., unusual expansion of both cell volume and the plasma membrane, and multi-nuclei) and failed to differentiate into myotubes possibly due to increased Ca2+ content in the SR. These results suggest that TRPC3 plays an important role in the maintenance of skeletal muscle myoblasts and myotubes.
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참고문헌 (26)
참고문헌 신청
Abramowitz J / 2009 / Physiology and pathophysiology of canonical transient receptor potential channels / FASEB J 23 : 297 ~ 328
Alberts B / 2008 / Molecular Biology of the Cell / Garland Science
Benchimol S / 2001 / p53-dependent pathways of apoptosis / Cell Death Differ 8 : 1049 ~ 1051
Brotto MA / 2004 / Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice / Cell Res 14 : 373 ~ 378
Eun Hui Lee / 2006 / Interplay Between Intra- and Extracellular Calcium Ions / 분자와 세포 21 (3) : 315 ~ 329
Alberts B / 2008 / Molecular Biology of the Cell / Garland Science
Benchimol S / 2001 / p53-dependent pathways of apoptosis / Cell Death Differ 8 : 1049 ~ 1051
Brotto MA / 2004 / Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice / Cell Res 14 : 373 ~ 378
Eun Hui Lee / 2006 / Interplay Between Intra- and Extracellular Calcium Ions / 분자와 세포 21 (3) : 315 ~ 329
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