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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 471 - 478 (8page)
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초록· 키워드
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A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of action in LDL receptor-deficient (Ldlr-/-) mice. HMB-TZD Treatment reduced leukotriene B4 (LTB4) production significantly in RAW264.7macrophages and SVEC4-10 endothelial cells.
Macrophages or endothelial cells pre-incubated with HMB-TZD for 2 h and then stimulated with lipopolysaccharide or tumor necrosis factor-alpha (TNF-α) displayed reduced cytokine production. Also, HMB-TZD reduced cell migration and adhesion in accordance with decreased proinflammatory molecule production in vitro and ex vivo. HMB-TZD treatment of 8-week-old male Ldlr-/- mice resulted in significantly reduced atherosclerotic lesions without a change to plasma lipid profiles. Moreover, aortic expression of pro-atherogenic molecules involved in the recruitment of monocytes to the aortic wall, including TNF-α , MCP-1, and VCAM-1, was downregulated. HMB-TZD also reduced macrophage infiltration into atherosclerotic lesions. In conclusion, HMB-TZD ameliorates atherosclerotic lesion formation possibly by reducing the expression of proinflammatory molecules and monocyte/macrophage recruitment to the lesion. These results suggest that HMB-TZD, and benzylidenethiazole analogs in general, may have therapeutic potential as treatments for atherosclerosis.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)
Aiello RJ / 2002 / Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice / Arterioscler Thromb Vasc Biol 22 : 443 ~ 449
Berger W / 2007 / Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease / Int J Clin Pract 61 : 663 ~ 676
Choi JH / 2010 / Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice / ATHEROSCLEROSIS 212 (1) : 146 ~
Dwyer JH / 2004 / Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis / N Engl J Med 350 : 29 ~ 37
Aiello RJ / 2002 / Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice / Arterioscler Thromb Vasc Biol 22 : 443 ~ 449
Berger W / 2007 / Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease / Int J Clin Pract 61 : 663 ~ 676
Choi JH / 2010 / Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice / ATHEROSCLEROSIS 212 (1) : 146 ~
Dwyer JH / 2004 / Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis / N Engl J Med 350 : 29 ~ 37
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