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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 495 - 504 (10page)
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초록· 키워드
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Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-), c-Fos (c-Fos-/-) and arrestin/transducin (Sag-/-/Gnat1-/-), were examined. We measured the expression levels of thousands of genes in order to investigate their roles in phototransduction signaling in light-induced retinal degeneration using DNA microarray technology and then further explored the gene network using pathway analysis tools. Several cascades of gene components were induced or inhibited as a result of corresponding gene knockout under specific light conditions. Transducin deletion blocked the apoptotic signaling induced by exposure to low light conditions, and it did not require c-Fos/AP-1. Deletion of c-Fos blocked the apoptotic signaling induced by exposure to high intensity light. In the present study, we identified many gene transcripts that are essential for the initiation of light-induced rod degeneration and proposed several important networks that are involved in pro- and anti-apoptotic signaling. We also demonstrated the different cascades of gene components that participate in apoptotic signaling under specific light conditions.
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참고문헌 (25)
참고문헌 신청
Andley UP / 2007 / Crystallins in the eye: Function and pathology / Prog Retin Eye Res 26 : 78 ~ 98
Angel P / 1991 / The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation / Biochim Biophys Acta 1072 : 129 ~ 57
Calvert PD / 2000 / Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit / Proc Natl Acad Sci USA 97 : 13913 ~ 8
Chang GQ / 1993 / Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice / Neuron 11 : 595 ~ 605
Chen CK / 1999 / Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase / Proc Natl Acad Sci USA 96 : 3718 ~ 22
Angel P / 1991 / The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation / Biochim Biophys Acta 1072 : 129 ~ 57
Calvert PD / 2000 / Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit / Proc Natl Acad Sci USA 97 : 13913 ~ 8
Chang GQ / 1993 / Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice / Neuron 11 : 595 ~ 605
Chen CK / 1999 / Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase / Proc Natl Acad Sci USA 96 : 3718 ~ 22
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