지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 121 - 128 (8page)
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초록· 키워드
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Blood cells are transported into the brain and are thought to participate in neurodegenerative processes following hypoxic ischemic injury. We examined the possibility that transient forebrain ischemia (TFI)causes the blood-brain barrier (BBB) to become permeable to blood cells, possibly via dysfunction and degeneration of endothelial cells in rats. Extravasation of Evans blue and immunoglobulin G (IgG) was observed in the hippocampal CA1-2 areas within 8 h after TFI, and peaked at 48 h. This extravasation was accompanied by loss of tight junction proteins, occludin, and zonula occludens-1, and degeneration of endothelial cells in the CA1-2 areas. Iron overload and mitochondrial free radical production were evident in the microvessel endothelium of the hippocampus before endothelial cell damage occurred. Administration of deferoxamine (DFO), an iron chelator, or Neu2000, an antioxidant,blocked free radical production and endothelial cell degeneration. Our findings suggest that iron overload and iron-mediated free radical production cause loss of tight junction proteins and degeneration of endothelial cells, opening of the BBB after TFI.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Abbott NJ / 2010 / Structure and function of the blood-brain barrier / Neurobiol Dis 37 : 13 ~ 25
Abraham CS / 2002 / Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats / Cell Mol Neurobi
Belayev L / 1996 / Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats / Brain Res 739 : 88 ~ 96
Bralet J / 1992 / Effect of acidosis and anoxia on iron delocalization from brain homogenates / Biochem Pharmacol 43 : 979 ~ 983
Burdo JR / 2004 / Regulation of the profile of iron-management proteins in brain microvasculature / J Cereb Blood Flow Metab 24 : 67 ~ 74
Abraham CS / 2002 / Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats / Cell Mol Neurobi
Belayev L / 1996 / Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats / Brain Res 739 : 88 ~ 96
Bralet J / 1992 / Effect of acidosis and anoxia on iron delocalization from brain homogenates / Biochem Pharmacol 43 : 979 ~ 983
Burdo JR / 2004 / Regulation of the profile of iron-management proteins in brain microvasculature / J Cereb Blood Flow Metab 24 : 67 ~ 74
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