지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 129 - 137 (9page)
이용수
초록· 키워드
오류제보하기
The incidence rates of urinary bladder cancer continue to rise yearly, and thus new therapeutic approaches and early diagnostic markers for bladder cancer are urgently needed. Thus, identifying the key mediators and molecular mechanisms responsible for the survival of bladder cancer has valuable implications for the development of therapy. In this study, the role of BLT2, a receptor for leukotriene B4 (LTB4) and 12(S)-hydroxyeicosatetraenoic acid (HETE), in the survival of bladder cancer 253J-BV cells was investigated. We found that the expression of BLT2 is highly elevated in bladder cancer cells. Also, we observed that blockade of BLT2with an antagonist or BLT2 siRNA resulted in cell cycle arrest and apoptotic cell death, suggesting a role of BLT2 in the survival of human bladder cancer 253J-BV cells. Further experiments aimed at elucidating the mechanism by which BLT2 mediates survival revealed that enhanced level of reactive oxygen species (ROS)are generated via a BLT2-dependent up-regulation of NADPH oxidase members NOX1 and NOX4. Additionally,we observed that inhibition of ROS generation by either NOX1/4 siRNAs or treatment with an ROS-scavenging agent results in apoptotic cell death in 253J-BV bladder cancer cells. These results demonstrated that a ‘BLT2-NOX1/4-ROS’ cascade plays a role in the survival of this aggressive bladder cancer cells, thus pointing to BLT2 as a potential target for anti-bladder cancer therapy.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Chamulitrat W / 2003 / Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes / Oncogene 22 : 604
Choi JA / 2008 / Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells / FREE RADICAL BIOL MED 44 : 624 ~ 634
Choi JA / 2010 / Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway / Carcinogenesis 31 :
Cordon-Cardo C / 2008 / Molecular alterations associated with bladder cancer initiation and progression / Scand J Urol Nephrol Suppl 218 : 154 ~ 165
Guo J / 2007 / Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells / J Biol Chem 282 : 24364 ~ 24372
Choi JA / 2008 / Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells / FREE RADICAL BIOL MED 44 : 624 ~ 634
Choi JA / 2010 / Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway / Carcinogenesis 31 :
Cordon-Cardo C / 2008 / Molecular alterations associated with bladder cancer initiation and progression / Scand J Urol Nephrol Suppl 218 : 154 ~ 165
Guo J / 2007 / Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells / J Biol Chem 282 : 24364 ~ 24372
이 논문의 저자 정보
최근 본 자료
댓글(0)
0