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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 149 - 157 (9page)
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Many proteins consist of distinctive domains that can act independently or cooperatively to achieve a unique function. As these domains evolve from a naturally existing repertoire of functional domains, this implies that domain organization is an intrinsic element involved in building the complex structure and function of proteins. Thus, identifying functional domains would appear to be critical to the elucidation of questions related to protein evolution, folding, and the engineering of hybrid proteins for tailored applications. However, the simple application of “ego-like assembly”to the engineering of hybrid proteins is an oversimplification, as many hybrid constructs lack structural stability, usually due to unfavorable domain contacts. Thus, directed evolution, along with computational studies, may help to engineer hybrid proteins with improved physico-chemical properties. Accordingly, this paper introduces several approaches to functional hybrid protein engineering that potentially can be used to create modulators of gene transcription and cell signaling, and novel biosensors to analyze biological functions in vivo.
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참고문헌 (27)
참고문헌 신청
Allert, M. / 2007 / Local encoding of computationally designed enzyme activity / J. Mol. Biol 366 : 945 ~ 953
Arnold, F. H. / 2001 / Combinatorial and computational challenges for biocatalyst design / Nature 409 : 253 ~ 257
Arnold, F. H. / 2003 / Method in Molecular Biology, vol.230, Directed enzyme evolution: Screening and selection methods / Human Press Inc
Bhattacharyya, R. P. / 2006 / Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits / Annu. Rev. Biochem 75
Bishop, A. / 2000 / Unnatural ligands for engineered proteins: new tools for chemical genetics / Ann. Rev. Biophys. Biomol. Struct 29 : 577 ~ 606
Arnold, F. H. / 2001 / Combinatorial and computational challenges for biocatalyst design / Nature 409 : 253 ~ 257
Arnold, F. H. / 2003 / Method in Molecular Biology, vol.230, Directed enzyme evolution: Screening and selection methods / Human Press Inc
Bhattacharyya, R. P. / 2006 / Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits / Annu. Rev. Biochem 75
Bishop, A. / 2000 / Unnatural ligands for engineered proteins: new tools for chemical genetics / Ann. Rev. Biophys. Biomol. Struct 29 : 577 ~ 606
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