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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제8호
- 발행연도
- 2011.1
- 수록면
- 874 - 883 (10page)
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초록· 키워드
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Many studies have shown that the steamed root of Rehmannia glutinosa (SRG), which is widely used in the treatment of various neurodegenerative diseases in the context of Korean traditional medicine, is effective for improving cognitive and memory impairments. The purpose of this study was to examine whether SRG extracts improved memory defects caused by administering scopolamine (SCO) into the brains of rats. The effects of SRG on the acetylcholinergic system and proinflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses of SRG (50, 100, and 200 mg/kg,i.p.) for 14 days, 1 h before scopolamine injection (2 mg/kg,i.p.). After inducing cognitive impairment via scopolamine administration, we conducted a passive avoidance test (PAT)and the Morris water maze (MWM) test as behavioral assessments. Changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) and the reactivity of acetylcholinesterase (AchE) in the hippocampus.
Daily administration of SRG improved memory impairment according to the PAT, and reduced the escape latency for finding the platform in the MWM. The administration of SRG consistently significantly alleviated memory-associated decreases in cholinergic immunoreactivity and decreased interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)mRNA expression in the hippocampus. The results demonstrated that SRG had a significant neuroprotective effect against the neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that SRG may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.
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참고문헌 (23)
참고문헌 신청
Blennow, K / 2006 / Alzheimer’s disease Review / Lancet 368 : 387 ~ 403
Blokand, A. / 2004 / A detailed analysis of rat’s spatial memory in a probe trial of a Morris task / Behav. Brain Res 154 : 71 ~ 75
Counts, S. E / 2008 / Galanin hyperimmervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer’s disease / Neurodegener.
Dashniani, M. G / 2009 / Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process / Georgian Med. News 166 :
Dickson, D. W. / 1993 / Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer’s disease / Glia 7 : 75 ~ 83
Blokand, A. / 2004 / A detailed analysis of rat’s spatial memory in a probe trial of a Morris task / Behav. Brain Res 154 : 71 ~ 75
Counts, S. E / 2008 / Galanin hyperimmervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer’s disease / Neurodegener.
Dashniani, M. G / 2009 / Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process / Georgian Med. News 166 :
Dickson, D. W. / 1993 / Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer’s disease / Glia 7 : 75 ~ 83
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