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논문 기본 정보
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- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 242 - 247 (6page)
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In the fungal pathogen Candida albicans, the yeast-tohyphal
transition occurs in response to a broad range of
environmental stimuli and is considered to be a major
virulence factor. To address whether the zinc homeostasis
affects the growth or pathogenicity of C. albicans, we
functionally characterized the zinc-finger protein Csr1
during filamentation. The deduced amino acid sequence
of Csr1 showed a 49% similarity to the zinc-specific
transcription factor, Zap1 of Saccharomyces cerevisiae.
Sequential disruptions of CSR1 were carried out in diploid
C. albicans. The csr1/csr1 mutant strain showed severe
growth defects under zinc-limited growth conditions and
the filamentation defect under hypha-inducing media. The
colony morphology and the germ-tube formation were
significantly affected by the csr1 mutation. The expression
of the hyphae-specific gene HWP1 was also impaired in
csr1/csr1 cells. The C. albicans homologs of ZRT1 and
ZRT2, which are zinc-transporter genes in S. cerevisiae,
were isolated. High-copy number plasmids of these genes
suppressed the filamentation defect of the csr1/csr1 mutant
strain. We propose that the filamentation phenotype of C.
albicans is closely associated with the zinc homeostasis in
the cells and that Csr1 plays a critical role in this regulation.
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참고문헌 (25)
참고문헌 신청
Adams, A. / 1997 / Methods in Yeast Genetics / Cold Spring Harbor Laboratory Press
Bedell, G. W. / 1979 / Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: Evidence for zinc-resistant and -sensitive pathways for myceliu
Bird, A. J. / 2000 / A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator / EMBO 19 : 3704 ~ 3713
Calderone, R. A. / 2001 / Virulence factors of Candida albicans / Trends Microbiol 9 : 327 ~ 335
Campo, A. G. Jr. / 1976 / Treatment of acrodermatitis enteropathica with zinc sulfate. Arch / Dermatol 112 : 687 ~ 689
Bedell, G. W. / 1979 / Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: Evidence for zinc-resistant and -sensitive pathways for myceliu
Bird, A. J. / 2000 / A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator / EMBO 19 : 3704 ~ 3713
Calderone, R. A. / 2001 / Virulence factors of Candida albicans / Trends Microbiol 9 : 327 ~ 335
Campo, A. G. Jr. / 1976 / Treatment of acrodermatitis enteropathica with zinc sulfate. Arch / Dermatol 112 : 687 ~ 689
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