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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 600 - 610 (11page)
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초록· 키워드
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A cancer-associated antigen gene (CAGE) was identified by serological analysis of a recombinant cDNA expression library (SEREX). The gene was identified by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera from patients with gastric cancer. CAGE was found to contain a D-E-A-D box domain and encodes a putative protein of 630 amino acids with possible helicase activity. The CAGE gene is widely expressed in various cancer tissues and cancer cell lines.
Demethylation plays a role in the activation of CAGE in certain cancer cell lines where the gene is not expressed.
The functional roles of CAGE in tumorigenesis, the molecular mechanisms of CAGE expression, and cell motility are also discussed.
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참고문헌 (26)
참고문헌 신청
Baylin, S. B. / 2000 / DNA hypermethylation in tumorigenesis: Epigenetics joins genetics / Trends Genet 16 : 168 ~ 174
Baylin, S. B. / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol / Genet 10 : 687 ~ 692
Bird, A. / 1992 / The essentials of DNA methylation / Cell 70 : 5 ~ 8
Boel, P. / 1995 / BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes / Immunity 2 : 167 ~ 175
Boon, T. / 1996 / Human tumor antigens recognized by T lymphocytes. J. Exp / Med 183 : 725 ~ 729
Baylin, S. B. / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol / Genet 10 : 687 ~ 692
Bird, A. / 1992 / The essentials of DNA methylation / Cell 70 : 5 ~ 8
Boel, P. / 1995 / BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes / Immunity 2 : 167 ~ 175
Boon, T. / 1996 / Human tumor antigens recognized by T lymphocytes. J. Exp / Med 183 : 725 ~ 729
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