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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제4호
- 발행연도
- 2016.1
- 수록면
- 637 - 647 (11page)
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Proliferating cell nuclear antigen (PCNA) is a critical eukaryotic replication accessory factor that supports DNA binding in DNA processing, such as DNA replication, repair, and recombination. PCNA consists of three toroidal-shaped monomers that encircle doublestranded DNA. The diverse functions of PCNA may be regulated by its interactions with partner proteins. Many of the PCNA partner proteins generally have a conserved PCNAinteracting peptide (PIP) motif, located at the N- or C- terminal region. The PIP motif forms a 310 helix that enters into the hydrophobic groove produced by an interdomain-connecting loop, a central loop, and a C-terminal tail in the PCNA. Post-translational modification of PCNA also plays a critical role in regulation of its function and binding partner proteins. Structural and biochemical studies of PCNA-protein will be useful in designing therapeutic agents, as well as estimating the outcome of anticancer drug development. This review summarizes the characterization of eukaryotic PCNA in relation to the protein structures, functions, and modifications, and interaction with proteins.
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참고문헌 (91)
참고문헌 신청
Armstrong AA / 2012 / Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2 / Nature 483:59~63
Bowman GD / 2004 / Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex / Nature 429:724~730
Bray CM / 2005 / DNA repair mechanisms in plants:crucial sensors and effectors for the maintenance of genome integrity / New Phytol 168:511~528
Bravo R / 1981 / Identification of a nuclear polypeptide (“cyclin”) whose relative proportion is sensitive to changes in the rate of cell proliferation and to transformation / Prog. Clin. Biol. Res 85:235~248
Bravo R / 1987 / Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ / Nature 326:511~528
Bowman GD / 2004 / Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex / Nature 429:724~730
Bray CM / 2005 / DNA repair mechanisms in plants:crucial sensors and effectors for the maintenance of genome integrity / New Phytol 168:511~528
Bravo R / 1981 / Identification of a nuclear polypeptide (“cyclin”) whose relative proportion is sensitive to changes in the rate of cell proliferation and to transformation / Prog. Clin. Biol. Res 85:235~248
Bravo R / 1987 / Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ / Nature 326:511~528
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