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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,483 - 1,490 (8page)
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초록· 키워드
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In this study, silver nanoparticles (AgNPs) were synthesized by the citrate reduction process and, with the assistance of n-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, were successfully loaded with the macromolecular drug vancomycin (VAM) to form AgNP-VAM bioconjugates. The synthesized AgNPs, VAM, and AgNP-VAM conjugate were characterized by UV-visible spectroscopy, zeta potential analysis, confocal microscopy, and transmission electron microscopy. The effect of loading VAM onto AgNPs was investigated by testing the internalization of the bioconjugate into Mycobacterium smegmatis.
After treatment with the AgNP-VAM conjugate, the bacterial cells showed a significant decrease in UV absorption, indicating that loading of the VAM on AgNPs had vastly improved the drug’s internalization compared with that of AgNPs. All the experimental assessments showed that, compared with free AgNPs and VAM, enhanced internalization had been successfully achieved with the AgNP-VAM conjugate, thus leading to significantly better delivery of the macromolecular drug into the M. smegmatis cell. The current research provides a new potential drug delivery system for the treatment of mycobacterial infections.
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참고문헌 (24)
참고문헌 신청
Anandhakumar S / 2013 / Polyelectrolyte/silver nanocomposite multilayer films as multifunctional thin film platforms for remote activated protein and drug delivery / Acta Bio
Aymonier C / 2002 / Hybrids of silver nanoparticles with amphiphilic hyperbranched macromolecules exhibiting antimicrobial properties / Chem. Commun 2002 : 3018 ~ 3019
Chen X / 2008 / Nanosilver: a nanoproduct in medical application / Toxicol. Lett 176 : 1 ~ 12
Cheon SA / 2016 / Recent tuberculosis diagnosis toward the end TB strategy / J. Microbiol. Methods 123 : 51 ~ 61
Duran N / 2007 / Antibacterial effect of silver nanoparticles produced by fungal process on textile fabrics and their effluent treatment / J. Biomed. Nanotechnol 3 : 203 ~ 2
Aymonier C / 2002 / Hybrids of silver nanoparticles with amphiphilic hyperbranched macromolecules exhibiting antimicrobial properties / Chem. Commun 2002 : 3018 ~ 3019
Chen X / 2008 / Nanosilver: a nanoproduct in medical application / Toxicol. Lett 176 : 1 ~ 12
Cheon SA / 2016 / Recent tuberculosis diagnosis toward the end TB strategy / J. Microbiol. Methods 123 : 51 ~ 61
Duran N / 2007 / Antibacterial effect of silver nanoparticles produced by fungal process on textile fabrics and their effluent treatment / J. Biomed. Nanotechnol 3 : 203 ~ 2
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