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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,539 - 1,548 (10page)
이용수
이 논문의 연구 히스토리 (2)
2017
Evaluation of the Adjuvant Activity of the De-O-acylated Lipooligosaccharide-based Adjuvant System CIA06 on Influenza Vaccine and P. aeruginosa Vaccine : 면역증강제시스템 CIA06의 인플루엔자 백신 및 녹농균 백신에 대한 면역증강활성 평가
류지인
생명공학과
2017.01
학위논문
Increased Immunogenicity and Protective Efficacy of a P. aeruginosa Vaccine in Mice Using an Alum and De-O-Acylated Lipooligosaccharide Adjuvant System
류지인
,
위서리
,
고아라
외 8명
Journal of Microbiology and Biotechnology
2017.01
학술저널
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초록· 키워드
오류제보하기
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that commonly causes fatal infections in cystic fibrosis and burn patients as well as in patients who are hospitalized or have impaired immune systems. P. aeruginosa infections are difficult to treat owing to the high resistance of the pathogen to conventional antibiotics. Despite several efforts, no effective prophylactic vaccines against P. aeruginosa are currently available. In this study, we investigated the activity of the CIA06 adjuvant system, which is composed of alum and de-Oacylated lipooligosaccharide, on a P. aeruginosa outer membrane protein (OMP) antigen vaccine in mice. The results indicated that CIA06 significantly increased the antigen-specific IgG titers and opsonophagocytic activity of immune sera against P. aeruginosa. In addition, the antibodies induced by the CIA06-adjuvanted vaccine exhibited higher cross-reactivity with heterologous P. aeruginosa strains. Finally, mice immunized with the CIA06-adjuvanted vaccine were effectively protected from lethal P. aeruginosa challenge. Based on these data, we suggest that the CIA06 adjuvant system might be used to promote the immunogenicity and protective efficacy of the P. aeruginosa OMP vaccine.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)
Alexander JW / 1971 / Immunological control of Pseudomonas infection in burn patients: a clinical evaluation / Arch. Surg 102 : 31 ~ 35
Bridge DR / 2016 / Heterologous Pseudomonas aeruginosa O-antigen delivery using a Salmonella enterica serovar Typhimurium wecA mutant strain / Int. J. Med. Microbiol 306 : 5
Campodonico VL / 2011 / Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice / Inf
Centers for Disease Control and Prevention / / Antibiotic resistance threats in the United States
Alexander JW / 1971 / Immunological control of Pseudomonas infection in burn patients: a clinical evaluation / Arch. Surg 102 : 31 ~ 35
Bridge DR / 2016 / Heterologous Pseudomonas aeruginosa O-antigen delivery using a Salmonella enterica serovar Typhimurium wecA mutant strain / Int. J. Med. Microbiol 306 : 5
Campodonico VL / 2011 / Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice / Inf
Centers for Disease Control and Prevention / / Antibiotic resistance threats in the United States
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