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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제11호
- 발행연도
- 2016.1
- 수록면
- 2,006 - 2,011 (6page)
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The marine sponges Hyrtios and Haliclona species, both of which are known to produce secondary bioactive metabolites, were used to extract 1304KO-327 and 1304KO-328. Such secondary metabolites are potentially antibacterial, antiviral, anti-inflammatory, antitumoral, antifungal, and antiplasmodial. In the present study, the effects of 1304KO-327 and 1304KO- 328 were studied for their clinical and pathological importance. The cytotoxicity of 1304KO- 327 and 1304KO-328 was assessed via MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on HT-29, Caco-2, and Raw 264.7 cells. Rotavirus-infected Caco-2 cells were used to prove the antiviral effects of the marine sponge extracts. The test results cogently proved that the virus-inhibiting effects of the sponge extracts improved with extract concentration. Anti-inflammatory effects of the marine sponge extracts were tested on Lipopolysaccharide-treated Raw 264.7 cells. Nitric oxide and cytokine were produced by treatment of the cells with LPS and the inhibiting effects of the sponge extracts on IL-1β formation were investigated. This study found that the NO production was decreased dose dependently, and IL-1β formation was significantly reduced by the marine sponge extracts.
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참고문헌 (36)
참고문헌 신청
Anderson AP / 1994 / Pharmacological properties of the natural marine product furospongin-1 / Clin. Exp. Pharmacol. Physiol 12:945~953
Aratake S / 2009 / A new polyunsaturated brominated fatty acid from a Haliclona sponge / Mar. Drugs 4:523~527
Ankisetty S / 2012 / Antibacterial secondary metabolites from the cave sponge Xestospongia sp / Mar. Drugs 10:1037~1043
Acosta AL / 1992 / 11-Oxoaerothionin: a cytotoxic antitumor bromotyrosine-derived alkaloid from the Caribbean marine sponge Aplysina lacunosa / J. Nat. Prod 7:1007~1012
Blunt JW / 2008 / Marine natural products / Nat. Prod. Rep 25:35~94
Aratake S / 2009 / A new polyunsaturated brominated fatty acid from a Haliclona sponge / Mar. Drugs 4:523~527
Ankisetty S / 2012 / Antibacterial secondary metabolites from the cave sponge Xestospongia sp / Mar. Drugs 10:1037~1043
Acosta AL / 1992 / 11-Oxoaerothionin: a cytotoxic antitumor bromotyrosine-derived alkaloid from the Caribbean marine sponge Aplysina lacunosa / J. Nat. Prod 7:1007~1012
Blunt JW / 2008 / Marine natural products / Nat. Prod. Rep 25:35~94
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