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논문 기본 정보
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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제6호
- 발행연도
- 2008.1
- 수록면
- 1,059 - 1,063 (5page)
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Abnormal phenotypes resulting from haploinsufficiency (HI)
are due to the loss of one allele. Recent studies in budding
yeast have shown that HI originates from insufficient
protein levels or from a stoichiometric imbalance between
subunits of protein complexes. In humans, however, HI
often involves transcription factors. Therefore, the species
differences in HI and the molecular mechanisms of speciesspecific
HI remain under investigation. In this study, HI in
fission yeast was systematically surveyed. HI in fission
yeast affected genes related to signaling and to basic cellular
processes, as observed in budding yeast. These results
suggest that there are species differences in HI and that
the HI that occurs in fission yeast is intermediate to HI in
budding yeast and humans.
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참고문헌 (19)
참고문헌 신청
ASENJO, J. A / 2007 / A Discrete Mathematical Model Applied to Genetic Regulation and Metabolic Networks / Journal of Microbiology and Biotechnology 17 (3) : 496 ~ 510
Chial, H. J. / 1999 / Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc. Natl. Acad / Sci 96 :
Contamine, V. / 2000 / Maintenance and integrity of the mitochondrial genome: A plethora of nuclear genes in the budding yeast. Microbiol. Mol. Biol / Rev 64 : 281 ~ 315
Deutschbauer, A. M. / 2005 / Mechanisms of haploinsufficiency revealed by genomewide profiling in yeast / Genetics 169 : 1915 ~ 1925
Drubin, D. G. / 1993 / Actin structure and function: Roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site.
Chial, H. J. / 1999 / Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Proc. Natl. Acad / Sci 96 :
Contamine, V. / 2000 / Maintenance and integrity of the mitochondrial genome: A plethora of nuclear genes in the budding yeast. Microbiol. Mol. Biol / Rev 64 : 281 ~ 315
Deutschbauer, A. M. / 2005 / Mechanisms of haploinsufficiency revealed by genomewide profiling in yeast / Genetics 169 : 1915 ~ 1925
Drubin, D. G. / 1993 / Actin structure and function: Roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site.
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