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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제10호
- 발행연도
- 2008.1
- 수록면
- 1,735 - 1,740 (6page)
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초록· 키워드
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Clone PERV-C (A3) env was isolated from the genomic
DNA of domestic pig (Sus scrofa domesticus) in Korea to
investigate the molecular properties of PERV-C. The
nucleic acid homologies between the PERV-MSL (type C)
reference and the PERV-C(A3) clone was 99% for
env, but a single base pair deletion was found in the
transmembrane (TM) region of the env open reading
frame. To examine the functional characteristics of
truncated PERV-C env, we constructed a replicationincompetent
retroviral vector by replacing the env gene of
the pCL-Eco retrovirus vector with PERV-C env. A
retroviral vector bearing PERV-C/A chimeric envelopes
was also created to complement the TM defect. Our
results indicated that truncated PERV-C env was not
infectious in human cells as expected. Interestingly,
however, the vector with the PERV-C/A envelope was able
to infect 293 cells. This observation suggests that
recombination within PERV-C TM could render PERV-C
infectious in humans. To further characterize PERV-C/A
envelopes, we constructed an infectious molecular clone
by using a PCR-based technique. This infectious molecular
clone will be useful to examine more specific regions that
are critical for human cell tropism.
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참고문헌 (24)
참고문헌 신청
Aguilar, H. C. / 2003 / Cytoplasmic tail of Moloney murine leukemia virus envelope protein influences the conformation of the extracellular domain: Implication for mechanism
Akiyoshi, D. E. / 1998 / Identification of a fulllength cDNA for an endogenous retrovirus of miniature swine / Virol 72 : 4503 ~ 4507
Bach, F. H. / 1998 / Uncertainty in xenotransplantation: Individual benefit versus collective risk / Nat. Med 4 : 141 ~ 144
Bartosch, B. / 2002 / PCR-based cloning and immunocytological titration of infectious porcine endogenous retrovirus subgroup A and / Gen. Virol 83 : 2231 ~ 2240
Bobkova, M. / 2002 / Identification of R-peptides in envelope proteins of C-type retroviruses / Gen. Virol 83 : 2241 ~ 2246
Akiyoshi, D. E. / 1998 / Identification of a fulllength cDNA for an endogenous retrovirus of miniature swine / Virol 72 : 4503 ~ 4507
Bach, F. H. / 1998 / Uncertainty in xenotransplantation: Individual benefit versus collective risk / Nat. Med 4 : 141 ~ 144
Bartosch, B. / 2002 / PCR-based cloning and immunocytological titration of infectious porcine endogenous retrovirus subgroup A and / Gen. Virol 83 : 2231 ~ 2240
Bobkova, M. / 2002 / Identification of R-peptides in envelope proteins of C-type retroviruses / Gen. Virol 83 : 2241 ~ 2246
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