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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제3호
- 발행연도
- 2015.1
- 수록면
- 407 - 412 (6page)
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초록· 키워드
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We investigated the effect of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) on hair loss in vitro and in vivo. 5-Alpha reductase is an enzyme that metabolizes the male hormone testosterone into dihydrotestosterone. By performing an in vitro experiment to analyze the inhibitory effects of UHMW γ-PGA on 5-alpha reductase activity, we determined that UHMW γ-PGA did in fact inhibit 5-alpha reductase activity, indicating the use of UHMW γ-PGA as a potential 5-alpha reductase inhibitor in the treatment of men with androgenetic alopecia. To evaluate the promotion of hair growth in vivo, we topically applied UHMW γ-PGA and minoxidil on the shaved dorsal skin of telogenic C57BL/6 mice for 4 weeks. At 4 weeks, the groups treated with UHMW γ-PGA showed hair growth on more than 50% of the shaved skin, whereas the control group showed less hair growth. To investigate the progression of hair follicles in the hair cycle, hematoxylin and eosin staining was performed. Histological observations revealed that the appearance of hair follicles was earlier in the UHMW γ-PGA-treated group than in the control group. The number of hair follicles on the relative area of shaved skin in the UHMW γ-PGA-treated group was higher than that observed on the shaved skin in the control group. These results indicate that UHMW γ-PGA can promote hair growth by effectively inducing the anagen phase in telogenic C57BL/6 mice.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adam ET / 2010 / Nonlinear multicontrast microscopy of hematoxylinand-eosin-stained histological sections / J. Biomed. Opt 15 : 026018 ~
Ashiuchi M / 2001 / Isolation of Bacillus subtilis (Chungkookjang), a poly-gamma-glutamate producer with high genetic competence / Appl. Microbiol. Biotechnol 57 : 764 ~ 769
D’Amico AV / 2007 / Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial / Lanc
Gelfuso GM / 2013 / Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia / J. Pharm. Sci 102 : 1488 ~ 1494
Gordon KA / 2011 / Alopecia: evaluation and treatment / Clin. Cosmet. Investig. Dermatol 4 : 101 ~ 106
Ashiuchi M / 2001 / Isolation of Bacillus subtilis (Chungkookjang), a poly-gamma-glutamate producer with high genetic competence / Appl. Microbiol. Biotechnol 57 : 764 ~ 769
D’Amico AV / 2007 / Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial / Lanc
Gelfuso GM / 2013 / Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia / J. Pharm. Sci 102 : 1488 ~ 1494
Gordon KA / 2011 / Alopecia: evaluation and treatment / Clin. Cosmet. Investig. Dermatol 4 : 101 ~ 106
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