지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제8호
- 발행연도
- 2015.1
- 수록면
- 1,195 - 1,204 (10page)
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초록· 키워드
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Increasing evidence suggests that gut microbiota underpin the development of health and longevity. However, our understanding of what influences the composition of this community of the longevous has not been adequately described. Therefore, illumina sequencing analysis was performed on the gut microbiota of centenarians (aged 100-108 years; RC) and younger elderlies (aged 85-99 years; RE) living in Bama County, Guangxi, China and the elderlies (aged 80-92 years; CE) living in Nanning City, Guangxi, China. In addition, their diet was monitored using a semiquantitative dietary questionary (FFQ 23). The results revealed the abundance of Roseburia and Escherichia was significantly greater, whereas that of Lactobacillus, Faecalibacterium, Parabacteroides, Butyricimonas, Coprococcus, Megamonas, Mitsuokella, Sutterella, and Akkermansia was significantly less in centenarians at the genus level. Both clustering analysis and UniFraq distance analysis showed structural segregation with age and diet among the three populations. Using partial least square discriminate analysis and redundancy analysis, we identified 33 and 34 operational taxonomic units (OTUs) as key OTUs that were significantly associated with age and diet, respectively. Age-related OTUs were characterized as Ruminococcaceae, Clostridiaceae, and Lachnospiraceae, and the former two were increased in the centenarians; diet-related OTUs were classified as Bacteroidales, Lachnospiraceae, and Ruminococcaceae. The former two were deceased, whereas the later one was increased, in the high-fiber diet. The age and high-fiber diet were concomitant with changes in the gut microbiota of centenarians, suggesting that age and high-fiber diet can establish a new structurally balanced architecture of gut microbiota that may benefit the health of centenarians.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지
Anonymous / 1996 / Use of geographic information systems in epidemiology (GIS-Epi) / Epidemiol. Bull 17 : 1 ~ 6
Backhed F / 2005 / Host-bacterial mutualism in the human intestine / Science 307 : 1915 ~ 1920
Biagi E / 2010 / Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians / PLoS One 5 : 1 ~ 14
Biagi E / 2012 / Ageing of the human metaorganism: the microbial counterpart / Age 34 : 247 ~ 267
Anonymous / 1996 / Use of geographic information systems in epidemiology (GIS-Epi) / Epidemiol. Bull 17 : 1 ~ 6
Backhed F / 2005 / Host-bacterial mutualism in the human intestine / Science 307 : 1915 ~ 1920
Biagi E / 2010 / Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians / PLoS One 5 : 1 ~ 14
Biagi E / 2012 / Ageing of the human metaorganism: the microbial counterpart / Age 34 : 247 ~ 267
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