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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제2호
- 발행연도
- 2009.1
- 수록면
- 208 - 214 (7page)
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초록· 키워드
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Steroid hormones have long been known to have a
profound influence on the immune system. Although the
functions of the nuclear receptors in the development of
T cells are fairly well studied, the differential expression of
these receptors in T helper cells is poorly understood.
Here, we investigated the differential expression of nuclear
receptors and coregulators in Th1 and Th2 cells by genomewide
microarray analysis. The result showed that several
nuclear receptors and coregulators are differentially expressed
in these cells. The result was confirmed by RT-PCR. The
result showed that RXRα is highly expressed in Th2 cells.
Overexpression of RXRα in a Jurkat human T cell line induced
IL4 but not IFN-γ gene expression, suggesting that RXRα
plays a selective role in Th1 and Th2 differentiation. In
summary, these results suggest that Th1/Th2 differentiation
is influenced by differential regulation of nuclear receptors
and coregulators.
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참고문헌 (25)
참고문헌 신청
Abbas, A. K. / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Cantorna, M. T. / 1995 / Vitamin A deficiency results in a priming environment conducive for Th1 cell development / Eur. J. Immunol 25 : 1673 ~ 1679
Dong, C. / 2001 / Th1 and Th2 cells / Curr. Opin. Hematol 8 : 47 ~ 51
Du, X. / 2005 / An essential role for Rxrα in the development of Th2 responses / Eur. J. Immunol 35 : 3414 ~ 3423
Dzhagalov, I. / 2004 / Lymphocyte development and function in the absence of retinoic acid-related orphan receptor α / J. Immunol 173 : 2952 ~ 2959
Cantorna, M. T. / 1995 / Vitamin A deficiency results in a priming environment conducive for Th1 cell development / Eur. J. Immunol 25 : 1673 ~ 1679
Dong, C. / 2001 / Th1 and Th2 cells / Curr. Opin. Hematol 8 : 47 ~ 51
Du, X. / 2005 / An essential role for Rxrα in the development of Th2 responses / Eur. J. Immunol 35 : 3414 ~ 3423
Dzhagalov, I. / 2004 / Lymphocyte development and function in the absence of retinoic acid-related orphan receptor α / J. Immunol 173 : 2952 ~ 2959
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