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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제2호
- 발행연도
- 2009.1
- 수록면
- 155 - 160 (6page)
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초록· 키워드
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Mast cells and basophils perform important functions as
pivotal effector cells in IgE-mediated allergic reactions.
KU812F cells, a human basophilic cell line isolated originally
from chronic myelocytic leukemia, express a high affinity
receptor of IgE, FcεRI. Kaempferol was extracted and
isolated from a methanolic extract of flavonoid-rich Nelumbo
nucifera stamens. In the present study, the inhibitory
effects of kaempferol on FcεRI expression in human
basophilic KU812F cells was examined. Flow cytometric
analysis revealed that FcεRI expression on the cell surface
was suppressed in a concentration-dependent manner when
the cells were cultured with kaempferol. Moreover, RTPCR
analysis showed that the mRNA levels for FcεRI α-
and γ-chains were reduced as the result of kaempferol
treatment in a concentration-dependent manner. Kaempferol
showed its suppressive effects on intracellular Ca2+
concentration and histamine release from anti-FcεRI α-
chain antibody-stimulated cells in a concentration-dependent
manner. These observations indicate that kaempferol may
exert antiallergic effect via downregulation of FcεRI
expression and degranulation.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물
Amoui, M. / 1997 / Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type Fc epsilon receptors / Eur. J. Immunol 27 :
Blank, U. / 1989 / Complete structure and expression in transfected cells of high affinity IgE receptor / Nature 337 : 187 ~ 189
Cho, E. J. / 2003 / Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical / Phytomedicine 14 : 544
Drombrowicz, D. / 1993 / Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor ε chain gene / Cell 75 : 969 ~ 976
Amoui, M. / 1997 / Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type Fc epsilon receptors / Eur. J. Immunol 27 :
Blank, U. / 1989 / Complete structure and expression in transfected cells of high affinity IgE receptor / Nature 337 : 187 ~ 189
Cho, E. J. / 2003 / Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical / Phytomedicine 14 : 544
Drombrowicz, D. / 1993 / Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor ε chain gene / Cell 75 : 969 ~ 976
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