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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제24권 제3호
- 발행연도
- 2014.1
- 수록면
- 371 - 378 (8page)
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The aim of the present study was to investigate the antigenotoxic properties of the probioticLactobacillus rhamnosus IMC501; DNA damage was induced by one representative foodmutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mice were treated orallywith suspensions of lactobacilli for 10 days before administration of food mutagen. During thetreatment, the abundance of lactobacilli in feces, as assessed by qPCR analysis, increased,whereas β-glucuronidase and N-acetyl-β-glucosaminidase activities decreased. The extent ofDNA damage was measured in colon and liver cells by comet assay. In colonocytes, dietsupplementation with IMC501 resulted in a significant inhibition of DNA damage induced byPhIP. The results obtained in this in vitro study suggest that Lactobacillus rhamnosus IMC501used as a dietary supplement can provide a useful integration of antimutagen foodcomponents of the normal diet, which are generally lower than the protective level.
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참고문헌 (24)
참고문헌 신청
Allsopp P / 2009 / Prebiotics and Probiotics Science and Technology / Springer : 997 ~ 1048
Blaut M / 2007 / Metabolic diversity of the intestinal microbiota: implications for health and disease / J. Nutr 137 : 751 ~ 755
Burns AJ / 2004 / Antigenotoxicity of probiotics and prebiotics on faecal water-induced DNA damage in human colon adenocarcinoma cells / Mutat. Res 551 : 233 ~ 243
Caldini G / 2005 / Screening of potential lactobacilli antigenotoxicity by microbial and mammalian cell-based tests / Int. J. Food Microbiol 102 : 37 ~ 47
Capurso G / 2006 / Probiotics and the incidence of colorectal cancer: when evidence is not evident / Dig. Liver Dis 38 : 277 ~ 282
Blaut M / 2007 / Metabolic diversity of the intestinal microbiota: implications for health and disease / J. Nutr 137 : 751 ~ 755
Burns AJ / 2004 / Antigenotoxicity of probiotics and prebiotics on faecal water-induced DNA damage in human colon adenocarcinoma cells / Mutat. Res 551 : 233 ~ 243
Caldini G / 2005 / Screening of potential lactobacilli antigenotoxicity by microbial and mammalian cell-based tests / Int. J. Food Microbiol 102 : 37 ~ 47
Capurso G / 2006 / Probiotics and the incidence of colorectal cancer: when evidence is not evident / Dig. Liver Dis 38 : 277 ~ 282
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