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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제7호
- 발행연도
- 2016.1
- 수록면
- 1,198 - 1,205 (8page)
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초록· 키워드
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Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heatkilled W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappalight- chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun Nterminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Aybay C / 1998 / Comparison of the effects of Salmonella minnesota Re595 lipopolysaccharide, lipid A and monophosphoryl lipid A on nitric oxide, TNF-alpha, and IL-6 induction from RAW 264.7 macrophages / FEMS Immunol. Med. Microbiol 22:263~273
Boulton TG / 1991 / Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies / Cell Regul 2:357~371
De Kimpe SJ / 1995 / The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure / Proc. Natl. Acad. Sci. USA 92:10359~10363
Dong C / 2002 / MAP kinases in the immune response / Annu. Rev. Immunol 20:55~72
Draing C / 2006 / Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae / J. Biol. Chem 281:33849~33859
Boulton TG / 1991 / Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies / Cell Regul 2:357~371
De Kimpe SJ / 1995 / The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure / Proc. Natl. Acad. Sci. USA 92:10359~10363
Dong C / 2002 / MAP kinases in the immune response / Annu. Rev. Immunol 20:55~72
Draing C / 2006 / Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae / J. Biol. Chem 281:33849~33859
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