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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 1,005 - 1,009 (5page)
이용수
초록· 키워드
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Primary cytomegalovirus (CMV) infection during pregnancy can cause congenital defects.
Available data for CMV infection during pregnancy in north China are inadequate. The aim of this study was to evaluate the epidemiology of maternal CMV infection and explore the incidence of congenital infection. In this prospective study, serum CMV IgG and IgM antibodies were measured in 2,887 pregnant women using ELISA, and the IgG avidity test was performed on all IgM-positive subjects. The seroprevalence of anti-CMV IgG was 94.70%, and of anti-CMV IgM was 1.28%. CMV IgG prevalence increased significantly with age (p < 0.01).
Women living in downtown areas showed higher IgG prevalence than those residing in urban areas (p = 0.023). CMV-IgM seroprevalence was highest in autumn (p = 0.021). There was no difference in IgM seroprevalence by age, socioeconomic status, geographical area, or gravida.
The rate of primary CMV infection was 0.45% (13/2,887) at the first trimester. The seroconversion rate during pregnancy was 0.76% (22/2,887). One woman underwent seroconversion during pregnancy and gave birth to an infant with asymptomatic CMV infection. Congenital CMV infection was diagnosed in five of the 14 infants from 14 mothers with active infection, for a vertical transmission rate of 35.71% (5/14). Three infants were asymptomatic, whereas two infants presented symptomatic infection with hearing deficits.
Although CMV IgG prevalence is relatively high in north China, significant attention to primary CMV infection during pregnancy is still needed.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adams WK / 2013 / Influence of infection during pregnancy on fetal development / Reproduction 146 : R151 ~ R162
Bate SL / 2010 / Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004 / Clin. Infect. Dis 50 : 1439 ~ 1447
Boppana SB / 2001 / Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity / N. Engl. J. Med 344 : 1366 ~ 1371
Cannon MJ / 2010 / Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection / Rev. Med. Virol 20 : 202 ~ 213
Dollard SC / 2007 / New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection / Rev. Med. Virol
Bate SL / 2010 / Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004 / Clin. Infect. Dis 50 : 1439 ~ 1447
Boppana SB / 2001 / Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity / N. Engl. J. Med 344 : 1366 ~ 1371
Cannon MJ / 2010 / Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection / Rev. Med. Virol 20 : 202 ~ 213
Dollard SC / 2007 / New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection / Rev. Med. Virol
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