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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제11호
- 발행연도
- 2017.1
- 수록면
- 1,916 - 1,924 (9page)
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In this study, we synthesized a glycosylated derivative of caffeic acid phenethyl ester (CAPE) using the amylosucrase from Deinococcus geothermalis with sucrose as a substrate and examined its solubility, chemical stability, and anti-inflammatory activity. Nuclear magnetic resonance spectroscopy showed that the resulting glycosylated CAPE (G-CAPE) was the new compound caffeic acid phenethyl ester-4-O-α-D-glucopyranoside. G-CAPE was 770 times more soluble than CAPE and highly stable in Dulbecco’s modified Eagle’s medium and buffered solutions, as estimated by its half-life. The glycosylation of CAPE did not significantly affect its anti-inflammatory activity, which was assessed by examining lipopolysaccharide-induced nitric oxide production and using a nuclear factor erythroid 2-related factor 2 reporter assay.
Furthermore, a cellular uptake experiment using high-performance liquid chromatography analysis of the cell-free extracts of RAW 264.7 cells demonstrated that G-CAPE was gradually converted to CAPE within the cells. These results demonstrate that the glycosylation of CAPE increases its bioavailability by helping to protect this vital molecule from chemical or enzymatic oxidation, indicating that G-CAPE is a promising candidate for prodrug therapy.
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참고문헌 (22)
참고문헌 신청
[학술지(
Akyol S / 2012 / The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapyinduced toxicity / Cell Biochem. Funct 30 : 438 ~ 44
Armutcu F / 2015 / Therapeutic potential of caffeic acid phenethyl ester and its antiinflammatory and immunomodulatory effects (Review) / Exp. Ther. Med 9 : 1582 ~ 1588
Chiao C / 1995 / Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells / Cancer Res 55 : 3576 ~ 3583
Couvreur P / 2012 / Nanotechnologies for designing new medicines / Biol. Aujourdhui 206 : 237 ~ 248
Akyol S / 2012 / The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapyinduced toxicity / Cell Biochem. Funct 30 : 438 ~ 44
Armutcu F / 2015 / Therapeutic potential of caffeic acid phenethyl ester and its antiinflammatory and immunomodulatory effects (Review) / Exp. Ther. Med 9 : 1582 ~ 1588
Chiao C / 1995 / Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells / Cancer Res 55 : 3576 ~ 3583
Couvreur P / 2012 / Nanotechnologies for designing new medicines / Biol. Aujourdhui 206 : 237 ~ 248
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