지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제7호
- 발행연도
- 2012.1
- 수록면
- 907 - 916 (10page)
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초록· 키워드
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Burkholderia cepacia is an important pathogen that often causes pneumonia in immunocompromised individuals.
Here, it was demonstrated that the TLR5 agonist flagellin could locally activate innate immunity. This was characterized by rapid expressions of IL-1β, TNF-α, and iNOS mRNA and a delay in the expression of IL-10mRNA. A significant elevation in the IL-1β, TNF-α, and nitric oxide levels was also noted. In the respiratory tract,flagellin induced neutrophil infiltration into the airways,which was observed by histopathological examination and confirmed by the neutrophil count and level of myeloperoxidase activity. This was concomitant with a high activity of alveolar macrophages that engulfed and killed B. cepacia in vitro. The flagellin mucosal treatment improved the B. cepacia clearance in the mouse lung.
Thus, the present findings illustrate the profound stimulatory effect of flagellin on the lung mucosal innate immunity, a response that needs to be exploited therapeutically to prevent the development of respiratory tract infection by B. cepacia.
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참고문헌 (47)
참고문헌 신청
Albiger, B. / 2005 / Myeloid differentiation factor 88- dependent signaling controls bacterial growth during colonization and systemic pneumococcal disease in mice / Cell Microbiol 7:1603~1615
Andersen-Nissen, E. / 2007 / Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection / J. Immunol 178:4717~4720
Araujo, A. / 2011 / Lymphohistiocytic activation syndrome and Burkholderia cepacia complex infection in a child revealing chronic granulomatous disease and chromosomal integration of the HHV-6 genome / Arch. Pediatr 18:416~419
Baldwin, A. S. / 1996 / The NF-kB and IkB proteins: New discoveries and insights / Annu. Rev. Immunol 14:649~681
Berrington, W. R. / 2007 / Mycobacterium tuberculosis, macrophages, and the innate immune response: Does common variation matter? / Immunol. Rev 219:167~186
Andersen-Nissen, E. / 2007 / Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection / J. Immunol 178:4717~4720
Araujo, A. / 2011 / Lymphohistiocytic activation syndrome and Burkholderia cepacia complex infection in a child revealing chronic granulomatous disease and chromosomal integration of the HHV-6 genome / Arch. Pediatr 18:416~419
Baldwin, A. S. / 1996 / The NF-kB and IkB proteins: New discoveries and insights / Annu. Rev. Immunol 14:649~681
Berrington, W. R. / 2007 / Mycobacterium tuberculosis, macrophages, and the innate immune response: Does common variation matter? / Immunol. Rev 219:167~186
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