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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제10호
- 발행연도
- 2015.1
- 수록면
- 1,648 - 1,652 (5page)
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초록· 키워드
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Azaphilone polyketides are synthesized by iterative non-reducing fungal polyketide synthases (NR-fPKSs) with a C-terminus reductive domain (-R). Several azaphilone biosynthetic gene clusters contain a putative serine hydrolase gene; the Monascus azaphilone pigment (MAzP) gene cluster harbors mppD. The MAzP productivity was significantly reduced by a knockout of mppD, and the MAzP NR-fPKS-R gene (MpPKS5) generated its product in yeast only when co-expressed with mppD. Site-directed mutations of mppD for conserved Ser/Asp/His residues abolished the product formation from the MpPKS5/mppD co-expression. MppD and its homologs are thus proposed as a new protein factor involved in the product formation of NR-fPKS-R.
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참고문헌 (22)
참고문헌 신청
Bailey AM / 2007 / Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosy
Balakrishnan B / 2013 / Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster / Appl. Microbiol. Biotechnol 97 : 6337 ~
Balakrishnan B / 2014 / Mpp7controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments / Tetrahedron Lett 55 : 1640 ~ 1643
Bijinu B / 2014 / Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis / RSC A
Bijinu Balakrishnan / 2014 / Monascus Azaphilone Pigment Biosynthesis Employs a Dedicated Fatty Acid Synthase for Short Chain Fatty Acyl Moieties / Applied Biological Chemist
Balakrishnan B / 2013 / Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster / Appl. Microbiol. Biotechnol 97 : 6337 ~
Balakrishnan B / 2014 / Mpp7controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments / Tetrahedron Lett 55 : 1640 ~ 1643
Bijinu B / 2014 / Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis / RSC A
Bijinu Balakrishnan / 2014 / Monascus Azaphilone Pigment Biosynthesis Employs a Dedicated Fatty Acid Synthase for Short Chain Fatty Acyl Moieties / Applied Biological Chemist
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