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- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제3호
- 발행연도
- 2013.1
- 수록면
- 297 - 303 (7page)
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Phylogenetic analysis of the groEL1 and xynB1 gene sequences from Sorangium cellulosum strains isolated in Korea previously revealed the existence of at least 5subgroups (A-E). In the present study, we used sequence analysis of polymerase chain reaction-amplified biosynthetic genes of strains from the 5 subgroups to indicate correlations between S. cellulosum subgroups and their secondary metabolic gene categories. We detected putative biosynthetic genes for disorazol, epothilone, ambruticin, and soraphen in group A, group C, group D, and group E strains,respectively. With the exception of KYC3204, culture extracts from group A, group B, and group C strains exhibited no noticeable antimicrobial inhibitory activities.
By contrast, culture extracts from group D strains inhibited the growth of Candida albicans, whereas culture extracts from group E strains inhibited the growth of C.
albicans and Staphylococcus aureus. High performance liquid chromatography analysis of the culture extracts from the strains of each subgroup revealed unique peak patterns. Our findings indicate the existence of at least 5subgroups of S. cellulosum strains, each of which has the potential to produce a unique set of secondary metabolites.
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참고문헌 (21)
참고문헌 신청
Altschul, S. F / 1990 / Basic local alignment search tool / J. Mol. Biol 215 : 403 ~ 410
Buntin, K. / 2010 / Biosynthesis of thuggacins in myxobacteria: Comparative cluster analysis reveals basis for natural product structural diversity / Chem. Biol 17 : 342 ~ 35
Frank, B / 2007 / Spiroketal polyketide formation in Sorangium: Identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes / Chem. Bio
Gerth, K / 2003 / Myxobacteria: Proficient producers of novel natural products with various biological activities - past and future biotechnological aspects with the focus on
Irschik, H / 2010 / Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assem
Buntin, K. / 2010 / Biosynthesis of thuggacins in myxobacteria: Comparative cluster analysis reveals basis for natural product structural diversity / Chem. Biol 17 : 342 ~ 35
Frank, B / 2007 / Spiroketal polyketide formation in Sorangium: Identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes / Chem. Bio
Gerth, K / 2003 / Myxobacteria: Proficient producers of novel natural products with various biological activities - past and future biotechnological aspects with the focus on
Irschik, H / 2010 / Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assem
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