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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제9호
- 발행연도
- 2017.1
- 수록면
- 1,628 - 1,638 (11page)
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초록· 키워드
오류제보하기
Viola tianshanica Maxim, belonging to the Violaceae plant family, is traditionally used in Uighur medicine for treating pneumonia, headache, and fever. There is, however, a lack of basic understanding of its pharmacological activities. This study was designed to observe the effects of the ethanol extract (TSM) from Viola tianshanica Maxim on the inflammation response in acute lung injury (ALI) induced by LPS and the possible underlying mechanisms.
We found that TSM (200 and 500 mg/kg) significantly decreased inflammatory cytokine production and the number of inflammatory cells, including macrophages and neutrophils, in bronchoalveolar lavage fluid. TSM also markedly inhibited the lung wet-to-dry ratio and alleviated pathological changes in lung tissues. In vitro, after TSM (12.5-100 μg/ml) treatment to RAW 264.7 cells for 1 h, LPS (1 μg/ml) was added and the cells were further incubated for 24 h. TSM dose-dependently inhibited the levels of proinflammatory cytokines, such as NO, PGE2, TNF-α, IL-6, and IL-1β, and remarkably decreased the protein and mRNA expression of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells. TSM also suppressed protein expression of p-IκBa and p-ERK1/2 and blocked nuclear translocation of NF-κB p65. The results indicate that TSM exerts anti-inflammatory effects related with inhibition on NF-κB and MAPK (p-ERK1/2) signaling pathways. In conclusion, our data demonstrate that TSM might be a potential agent for the treatment of ALI.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Yang J / 2010 / Protective effects of imipramine in murine endotoxin induced acute lung injury / Eur. J. Pharmacol 638:128~133
Bhatia M / 2004 / Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome / J. Pathol 202:145~156
Ware LB / 2000 / The acute respiratory distress syndrome / N. Engl. J. Med 342:1334~1349
Chu X / 2010 / Ceftiofur attenuates lipopolysaccharide-induced acute lung injury / Int. Immunopharmacol 10:600~604
Chen H / 2010 / The value o f the lipopolysaccharide-induced acute lung injury model in respiratory medicine / Expert Rev Respir. Med 4:773~783
Bhatia M / 2004 / Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome / J. Pathol 202:145~156
Ware LB / 2000 / The acute respiratory distress syndrome / N. Engl. J. Med 342:1334~1349
Chu X / 2010 / Ceftiofur attenuates lipopolysaccharide-induced acute lung injury / Int. Immunopharmacol 10:600~604
Chen H / 2010 / The value o f the lipopolysaccharide-induced acute lung injury model in respiratory medicine / Expert Rev Respir. Med 4:773~783
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