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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제9호
- 발행연도
- 2018.1
- 수록면
- 1,413 - 1,425 (13page)
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초록· 키워드
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Shiga toxins (Stxs) are the main virulence factors expressed by the pathogenic Stx-producing bacteria, namely, Shigella dysenteriae serotype 1 and certain Escherichia coli strains. These bacteria cause widespread outbreaks of bloody diarrhea (hemorrhagic colitis) that in severe cases can progress to life-threatening systemic complications, including hemolytic uremic syndrome (HUS) characterized by the acute onset of microangiopathic hemolytic anemia and kidney dysfunction. Shiga toxicosis has a distinct pathogenesis and animal models of Stxassociated HUS have allowed us to investigate this. Since these models will also be useful for developing effective countermeasures to Stx-associated HUS, it is important to have clinically relevant animal models of this disease. Multiple studies over the last few decades have shown that mice injected with purified Stxs develop some of the pathophysiological features seen in HUS patients infected with the Stx-producing bacteria. These features are also efficiently recapitulated in a non-human primate model (baboons). In addition, rats, calves, chicks, piglets, and rabbits have been used as models to study symptoms of HUS that are characteristic of each animal. These models have been very useful for testing hypotheses about how Stx induces HUS and its neurological sequelae. In this review, we describe in detail the current knowledge about the most well-studied in vivo models of Stx-induced HUS; namely, those in mice, piglets, non-human primates, and rabbits. The aim of this review is to show how each human clinical outcome-mimicking animal model can serve as an experimental tool to promote our understanding of Stx-induced pathogenesis.
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참고문헌 (127)
참고문헌 신청
Melton-Celsa AR / 2014 / Shiga toxin (Stx) classification, structure, and function / Microbiol. Spectr. 2
Lingwood CA / 2010 / Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect / FEBS Lett. 584:1879~1886
Johannes L / 2008 / Tracing the retrograde route in protein trafficking / Cell 135:1175~1187
Gargantini L / 1989 / Growth and puberal development in males with adreno-genital syndrome / Pediatr. Med. Chir. 11:597~602
Cherla RP / 2009 / Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway / Infect. Immun. 77:3919~3931
Lingwood CA / 2010 / Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect / FEBS Lett. 584:1879~1886
Johannes L / 2008 / Tracing the retrograde route in protein trafficking / Cell 135:1175~1187
Gargantini L / 1989 / Growth and puberal development in males with adreno-genital syndrome / Pediatr. Med. Chir. 11:597~602
Cherla RP / 2009 / Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway / Infect. Immun. 77:3919~3931
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